{
    "accession": "MITE0000191",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-12-01",
            "contributors": [
                "0009-0002-2037-5945",
                "0009-0001-9399-9671"
            ],
            "reviewers": [
                "0009-0001-3436-5302",
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 fixed erroneously stated product (patulin) and added reaction databaseId crosslinks."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0003-4819-2251"
            ],
            "comment": "Added cofactor information"
        }
    ],
    "enzyme": {
        "name": "PatG",
        "description": "Decarboxylase",
        "references": [
            "doi:10.1016/j.ijfoodmicro.2013.11.020"
        ],
        "databaseIds": {
            "uniprot": "A0A075TXZ1",
            "genpept": "AIG62133.1",
            "mibig": "BGC0000120"
        },
        "cofactors": {
            "inorganic": [
                "Zn"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Decarboxylation"
            ],
            "description": "Decarboxylation of 6-methylsalicylic in the patulin biosynthetic pathway",
            "reactionSMARTS": "[#6:1]1(:[#6:11]:[#6:10]:[#6:9]:[#6:7](-[#6:8]):[#6:3]:1-[#6](-[#8])=[#8])-[#8:2]>>[#6:1]1(:[#6:11]:[#6:10]:[#6:9]:[#6:7](-[#6:8]):[#6:3]:1)-[#8:2]",
            "reactions": [
                {
                    "substrate": "Cc1cccc(O)c1C(=O)O",
                    "products": [
                        "Cc1cccc(O)c1"
                    ],
                    "isIntermediate": true,
                    "description": "Conversion of 6-methylsalicylic acid to m-cresol"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1016/j.ijfoodmicro.2013.11.020"
                ]
            },
            "databaseIds": {
                "rhea": "23112",
                "ec": "4.1.1.52"
            }
        }
    ]
}