{
    "accession": "MITE0000187",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-11-22",
            "contributors": [
                "0000-0001-6660-2715"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "Reviewer 1 checked for factual correctness of submission, database ID crosslinks and references."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        }
    ],
    "enzyme": {
        "name": "HrmI",
        "description": "Heme oxygenase-like dinuclear iron enzyme",
        "references": [
            "doi:10.1021/jacs.1c10201",
            "doi:10.1002/anie.202113189"
        ],
        "databaseIds": {
            "uniprot": "F8S6W0",
            "genpept": "AEH41787.1",
            "mibig": "BGC0000374"
        },
        "cofactors": {
            "inorganic": [
                "Fe"
            ],
            "organic": [
                "Heme"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "description": "oxidation of lysine to nitronorleucine",
            "reactionSMARTS": "[#7]-[#6:2]-[#6:3]-[#6:4]-[#6:5]-[#6@@:6](-[#6:8](-[#8:10])=[#8:9])/[#7:7]>>[#7:7]/[#6@:6](-[#6:8](-[#8:10])=[#8:9])-[#6:5]-[#6:4]-[#6:3]-[#6:2]-[#7;+](-[#8;-])=[#8]",
            "reactions": [
                {
                    "substrate": "NCCCC[C@H](N)C(=O)O",
                    "products": [
                        "N[C@@H](CCCC[N+](=O)[O-])C(=O)O"
                    ],
                    "isIntermediate": false,
                    "description": "oxidation of lysine to nitronorleucine"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1021/jacs.1c10201",
                    "doi:10.1002/anie.202113189"
                ]
            }
        }
    ]
}