{
    "accession": "MITE0000186",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-11-21",
            "contributors": [
                "0000-0001-6660-2715"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "New entry. Reviwer checked entries, references and for factual correctness"
        }
    ],
    "enzyme": {
        "name": "HrmF",
        "description": "L-DOPA dioxygenase",
        "references": [
            "doi:10.1016/j.chembiol.2010.12.018"
        ],
        "databaseIds": {
            "uniprot": "F8S6V7",
            "genpept": "AEH41784.1",
            "mibig": "BGC0000374"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Other"
            ],
            "description": "extradiol cleavage of L-DOPA, rearrangement to alkylproline derivative",
            "reactionSMARTS": "[#7:1]\\[#6@:2](-[#6:11](-[#8:13])=[#8:12])-[#6:3]-[#6:4]1:[#6:10]:[#6:9](-[#8:14]):[#6:7](-[#8:8]):[#6:6]:[#6:5]:1>>[#6:3]1-[#6@@:2](/[#6:11](=[#8:12])-[#8:13])-[#7:1]-[#6:10]=[#6:4]-1-[#6:5]=[#6:6]-[#6:7](=[#8])-[#6:9](=[#8:8])-[#8:14]",
            "reactions": [
                {
                    "substrate": "N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O",
                    "products": [
                        "O=C(O)C(=O)C=CC1=CN[C@H](C(=O)O)C1"
                    ],
                    "isIntermediate": false,
                    "description": "extradiol cleavage of L-DOPA, rearrangement to alkylproline derivative"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1016/j.chembiol.2010.12.018"
                ]
            }
        }
    ]
}