{
    "accession": "MITE0000170",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-2992-1607",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 added reaction description"
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        }
    ],
    "enzyme": {
        "name": "ProsK",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1073/pnas.2310522120"
        ],
        "databaseIds": {
            "genpept": "WPM83319.1",
            "mibig": "BGC0003094"
        },
        "cofactors": {
            "inorganic": [
                "Fe"
            ],
            "organic": [
                "Heme"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Cyclization"
            ],
            "description": "Depside bond formation by oxidative ether formation.",
            "reactionSMARTS": "[#6:17]-[c:25]1[c:24][c:23](-[#8:19])[c:22](-[#6:16])[c:21](-[#8:18])[c:20]1-[#6:15](=[O:14])-[#8:13]-[c:12]1[c:10][c:9](-[#6:5])[c:8](-[#6:3](-[#8:1])=[O:2])[c:7](-[#8:4])[c:11]1-[#6:6]>>[#6:17]-[c:25]1[c:24][c:23](-[#8:19])[c:22](-[#6:16])[c:21]2-[#8:18]-[c:10]3[c:9](-[#6:5])[c:8](-[#6:3](-[#8:1])=[O:2])[c:7](-[#8:4])[c:11](-[#6:6])[c:12]3-[#8:13]-[#6:15](=[O:14])-[c:20]12",
            "reactions": [
                {
                    "substrate": "Cc1cc(O)c(C)c(O)c1C(=O)Oc1cc(C)c(C(=O)O)c(O)c1C",
                    "products": [
                        "Cc1cc(O)c(C)c2c1C(=O)Oc1c(C)c(O)c(C(=O)O)c(C)c1O2"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1073/pnas.2310522120"
                ]
            }
        }
    ]
}