{
    "accession": "MITE0000167",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-2992-1607",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 clarified description and replaced CXSMARTS with regular SMARTS."
        }
    ],
    "enzyme": {
        "name": "ProsD",
        "description": "Glyoxalase",
        "references": [
            "doi:10.1073/pnas.2310522120"
        ],
        "databaseIds": {
            "genpept": "WPM83323.1",
            "mibig": "BGC0003094"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydrolysis"
            ],
            "description": "Ring cleavage in the scope of detoxification.",
            "reactionSMARTS": "[#6:1]-[#8:2]-[#6@@:3]1(-[#6@@:25]2-[#6:11](-[#8:12]-[#6](-[#6:15]3:[#6:23](-[#8:24]\\2):[#6:21](-[#6:22]):[#6:19](-[#8:20]):[#6:18]:[#6:16]:3-[#6:17])=[#8])=[#6:9](-[#6:10])-[#6:7](=[#8:8])-[#6@:5]-1\\[#8:6])\\[#6:4]>>[#6:1]-[#8:2]-[#6@@:3]1(-[#6@:25](-[#6:11](=[#8:12])-[#6:9](-[#6:10])=[#6:7](-[#8:8])-[#6@:5]-1\\[#8:6])\\[#8:24]-[#6:23]1:[#6:15]:[#6:16](:[#6:18]:[#6:19](:[#6:21]:1-[#6:22])-[#8:20])-[#6:17])\\[#6:4]",
            "reactions": [
                {
                    "substrate": "CO[C@@]1(C)[C@H](O)C(=O)C(C)=C2OC(=O)c3c(C)cc(O)c(C)c3O[C@@H]21",
                    "products": [
                        "CO[C@@]1(C)[C@H](O)C(O)=C(C)C(=O)[C@@H]1Oc1cc(C)cc(O)c1C"
                    ],
                    "isIntermediate": false,
                    "description": "Detoxification of roseopurpurin C to aculeatusquinone by ring cleavage."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1073/pnas.2310522120"
                ]
            }
        }
    ]
}