{
    "accession": "MITE0000164",
    "status": "active",
    "comment": "Previously referenced retired MIBiG ID BGC0003093.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-8323-5416",
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 checked crosslinks and factual correctness, added reaction description. Reviewer 2 replaced CXSMARTS with normal SMARTS"
        },
        {
            "version": "2",
            "date": "2026-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBIG ID."
        }
    ],
    "enzyme": {
        "name": "PhoP",
        "description": "Short-chain dehydrogenases/reductase",
        "references": [
            "doi:10.1021/acs.orglett.2c01050"
        ],
        "databaseIds": {
            "uniprot": "UPI00205EBDF6",
            "genpept": "UPG58745.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Reduction"
            ],
            "description": "PhoP is a short-chain dehydrogenases/reductase responsible for a reductive cyclisation step in the biosynthesis of phomoxanthone A",
            "reactionSMARTS": "[#6:1]/[#6@:2]1-[#6:20](=[#8:21])-[#6:17](-[#6:18]-[#8:19])=[#6:6](-[#6:7](-[#6:9]2:[#6:15](-[#8:16]):[#6:14]:[#6:13]:[#6:12]:[#6:10]:2-[#8:11])=[#8:8])-[#6:4](=[#8:5])-[#6:3]-1>>[#6:1]/[#6@:2]1-[#6@@:20](/[#8:21])-[#6@:17]2(-[#8:11]-[#6:10]3:[#6:9](:[#6:15](:[#6:14]:[#6:13]:[#6:12]:3)-[#8:16])-[#6:7](=[#8:8])-[#6:6]-2=[#6:4](-[#8:5])-[#6:3]-1)/[#6:18]-[#8:19]",
            "reactions": [
                {
                    "substrate": "C[C@@H]1CC(=O)C(C(=O)c2c(O)cccc2O)=C(CO)C1=O",
                    "products": [
                        "C[C@@H]1CC(O)=C2C(=O)c3c(O)cccc3O[C@]2(CO)[C@@H]1O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/acs.orglett.2c01050"
                ]
            }
        }
    ]
}