{
    "accession": "MITE0000162",
    "status": "active",
    "comment": "Previously referenced retired MIBiG ID BGC0003093.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-8323-5416"
            ],
            "comment": "Initial entry. Reviewer 1 checked crosslinks and factual correctness, added reaction description."
        },
        {
            "version": "2",
            "date": "2026-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBIG ID."
        }
    ],
    "enzyme": {
        "name": "PhoG",
        "description": "Anthrone oxygenase",
        "references": [
            "doi:10.1021/acs.orglett.2c01050"
        ],
        "databaseIds": {
            "uniprot": "UPI00206D4B6A",
            "genpept": "UPG58736.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "description": "Responsible for the conversion of emodin anthrone to emodin by oxidation during biosynthesis of phomoxanthone A",
            "reactionSMARTS": "[#6:19]-[c:18]1[c:15][c:12](-[#8:16])[c:5]2-[#6:2](=[O:6])-[c:1]3[c:4](-[#8:10])[c:9][c:13](-[#8:17])[c:8][c:3]3-[#6:7]-[c:11]2[c:14]1>>[#6:19]-[c:18]1[c:15][c:12](-[#8:16])[c:5]2-[#6:2](=[O:6])-[c:1]3[c:4](-[#8:10])[c:9][c:13](-[#8:17])[c:8][c:3]3-[#6:7](=[O])-[c:11]2[c:14]1",
            "reactions": [
                {
                    "substrate": "Cc1cc(O)c2c(c1)Cc1cc(O)cc(O)c1C2=O",
                    "products": [
                        "Cc1cc(O)c2c(c1)C(=O)c1cc(O)cc(O)c1C2=O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/acs.orglett.2c01050"
                ]
            }
        }
    ]
}