{
    "accession": "MITE0000160",
    "status": "active",
    "comment": "Previously referenced retired MIBiG ID BGC0003093.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-8323-5416",
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 removed erroneous reaction belonging to PhoO. Reviewer 2 replaced CXSMARTS with regular SMARTS"
        },
        {
            "version": "2",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        },
        {
            "version": "3",
            "date": "2026-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBIG ID."
        }
    ],
    "enzyme": {
        "name": "PhoC",
        "description": "Short-chain dehydrogenases/reductase",
        "references": [
            "doi:10.1021/acs.orglett.2c01050"
        ],
        "databaseIds": {
            "uniprot": "UPI00205CF1EC",
            "genpept": "UPG58732.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Reduction"
            ],
            "description": "PhoD is a reductase responsible for the reduction of a double bond during biosynthesis of phomoxanthone A",
            "reactionSMARTS": "[#6:1]-[#6:2]1:[#6:14]:[#6:13]2:[#6:6](:[#6:7](:[#6:9]3-[#6:19](=[#8:20])-[#6:18]=[#6:16](-[#8:17])-[#6:15]-[#6:10]:3:[#6:11]:2-[#8:12])-[#8:8]):[#6:4](-[#8:5]):[#6:3]:1>>[#6:1]-[#6:2]1:[#6:14]:[#6:13]2:[#6:6](:[#6:7](:[#6:9]3-[#6:19](=[#8:20])-[#6:18]-[#6@@:16](/[#8:17])-[#6:15]-[#6:10]:3:[#6:11]:2-[#8:12])-[#8:8]):[#6:4](-[#8:5]):[#6:3]:1",
            "reactions": [
                {
                    "substrate": "Cc1cc(O)c2c(O)c3c(c(O)c2c1)CC(O)=CC3=O",
                    "products": [
                        "Cc1cc(O)c2c(O)c3c(c(O)c2c1)C[C@H](O)CC3=O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/acs.orglett.2c01050"
                ]
            }
        }
    ]
}