{
    "accession": "MITE0000159",
    "status": "active",
    "comment": "Previously referenced retired MIBiG ID BGC0003093.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-8323-5416"
            ],
            "comment": "Initial entry. Reviewer 1 checked crosslinks and factual correctness, added reaction description."
        },
        {
            "version": "2",
            "date": "2026-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBIG ID."
        }
    ],
    "enzyme": {
        "name": "PhoD",
        "description": "Dehydratase",
        "references": [
            "doi:10.1021/acs.orglett.2c01050"
        ],
        "databaseIds": {
            "uniprot": "UPI002070062C",
            "genpept": "UPG58733.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Dehydration"
            ],
            "description": "PhoD is a dehydratase responsible for the formation of the intermediate chrysophanol during biosynthesis of phomoxanthone A",
            "reactionSMARTS": "[#6:1]-[c:2]1[c:5][c:8](-[#8:4])[c:15]2[c:18](-[#8:14])[c:19]3-[#6:16](=[O:10])-[#6:11]-[#6@@H:7](-[#8:3])-[#6:12]-[c:17]3[c:13](-[#8:20])[c:9]2[c:6]1>>[#6:1]-[c:2]1[c:5][c:8](-[#8:4])[c:15]2-[#6:18](=[O:14])-[c:19]3[c:16](-[#8:10])[c:11][c:7][c:12][c:17]3-[#6:13](=[O:20])-[c:9]2[c:6]1",
            "reactions": [
                {
                    "substrate": "Cc1cc(O)c2c(O)c3c(c(O)c2c1)C[C@H](O)CC3=O",
                    "products": [
                        "Cc1cc(O)c2c(c1)C(=O)c1cccc(O)c1C2=O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/acs.orglett.2c01050"
                ]
            }
        }
    ]
}