{
    "accession": "MITE0000157",
    "status": "active",
    "comment": "Previously referenced retired MIBiG ID BGC0003093.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-8323-5416"
            ],
            "comment": "Initial entry. Reviewer 1 checked crosslinks and factual correctness, added reaction description."
        },
        {
            "version": "2",
            "date": "2026-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBIG ID."
        }
    ],
    "enzyme": {
        "name": "PhoL",
        "description": "Short-chain dehydrogenases/reductase",
        "references": [
            "doi:10.1021/acs.orglett.2c01050"
        ],
        "databaseIds": {
            "uniprot": "UPI00205DA260",
            "genpept": "UPG58741.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Reduction"
            ],
            "description": "PhoL is responsible for reduction of monodictyphenone towards the biosynthesis of phomoxanthone A",
            "reactionSMARTS": "[#6:1]-[c:2]1[c:5][c:8](-[#8:4])[c:15](-[#6:18](=[O:14])-[c:19]2[c:16](-[#8:10])[c:11][c:7][c:12][c:17]2-[#8:22])[c:9]([c:6]1)-[#6:13](-[#8:20])=[O:21]>>[#6:1]-[c:2]1[c:5][c:8](-[#8:4])[c:15](-[#6:18](=[O:14])-[c:19]2[c:16](-[#8:10])[c:11][c:7][c:12][c:17]2-[#8:22])[c:9](-[#6:13]-[#8:20])[c:6]1",
            "reactions": [
                {
                    "substrate": "Cc1cc(O)c(C(=O)c2c(O)cccc2O)c(C(=O)O)c1",
                    "products": [
                        "Cc1cc(O)c(C(=O)c2c(O)cccc2O)c(CO)c1"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/acs.orglett.2c01050"
                ]
            }
        }
    ]
}