{
    "accession": "MITE0000151",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-4129-2890",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer fixed reactions:substrate. Reviewer fixed reactions:products."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        },
        {
            "version": "3",
            "date": "2026-02-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed MIBiG reference - does not exist."
        }
    ],
    "enzyme": {
        "name": "PspC",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1039/c9ob00807a"
        ],
        "databaseIds": {
            "uniprot": "P0DUK3"
        },
        "cofactors": {
            "inorganic": [
                "Fe"
            ],
            "organic": [
                "Heme"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "description": "catalyzes three-step oxidations at the C-4 methyl group to carboxylic acid to yield soppiline C",
            "reactionSMARTS": "[#6:1]\\[#6:2]=[#6:3](/[#6:26])-[#6:4]-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]\\[#6:11]=[#6:12]/[#6:13]=[#6:14]/[#6:15]=[#6:16]\\[#6:17]-[c:18]1[c:19][c:20](-[#8:21])[c:22][c:23](-[#8:24])[c:25]1>>[#6:1]\\[#6:2]=[#6:3](\\[#6:4]-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]\\[#6:11]=[#6:12]/[#6:13]=[#6:14]/[#6:15]=[#6:16]\\[#6:17]-[c:18]1[c:19][c:20](-[#8:21])[c:22][c:23](-[#8:24])[c:25]1)-[#6:26](-[#8])=[O]",
            "reactions": [
                {
                    "substrate": "C/C=C(\\C)CCCCCCC/C=C\\C=C\\C=C/Cc1cc(O)cc(O)c1",
                    "products": [
                        "C/C=C(/CCCCCCC/C=C\\C=C\\C=C/Cc1cc(O)cc(O)c1)C(=O)O"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1039/c9ob00807a"
                ]
            },
            "databaseIds": {
                "rhea": "66944"
            }
        }
    ]
}