{
    "accession": "MITE0000145",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0002-6258-2080",
                "0000-0003-2992-1607",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer fixed reactionSMARTS:reactionSMARTS."
        },
        {
            "version": "2",
            "date": "2026-02-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added reaction description"
        }
    ],
    "enzyme": {
        "name": "AvaD",
        "description": "GNAT family N-acetyltransferase",
        "references": [
            "doi:10.1038/s41589-022-01246-6"
        ],
        "databaseIds": {
            "uniprot": "P9WEK5",
            "genpept": "UZP48216.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Acetylation"
            ],
            "description": "Acetylates the arginine of the diketopiperazine substrate",
            "reactionSMARTS": "[#7:1]-[#6:2](=[#7:3])-[#7:4]-[#6:5]-[#6:6]-[#6:7]-[#6@@H:8]-1-[#7:9]-[#6:10](=[O:11])-[#6@H:12](-[#6:13]-[c:14]2[o:22][n:21][c:20]3[c:19][c:18][c:17][c:16][c:15]23)-[#7:23]-[#6:24]-1=[O:25]>>[#6:1]-[#6:2](=[O:3])\\[#7:4]=[#6:5](/[#7:6])-[#7:7]-[#6:8]-[#6:9]-[#6:10]-[#6@@H:11]-1-[#7:12]-[#6:13](=[O:14])-[#6@H:15](-[#6:16]-[c:17]2[o:25][n:24][c:23]3[c:22][c:21][c:20][c:19][c:18]23)-[#7]-[#6]-1=[O]",
            "reactions": [
                {
                    "substrate": "N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2onc3ccccc23)NC1=O",
                    "products": [
                        "CC(=O)/N=C(\\N)NCCC[C@@H]1NC(=O)[C@H](Cc2onc3ccccc23)NC1=O"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1038/s41589-022-01246-6"
                ]
            }
        }
    ]
}