{
    "accession": "MITE0000144",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0002-6258-2080",
                "0000-0003-2992-1607",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 fixed reaction SMARTS numbering."
        }
    ],
    "enzyme": {
        "name": "AvaB",
        "description": "FAD-dependent monooxygenase ",
        "references": [
            "doi:10.1038/s41589-022-01246-6"
        ],
        "databaseIds": {
            "uniprot": "P9WEK3",
            "genpept": "UZP48214.1"
        }
    },
    "reactions": [
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            "tailoring": [
                "Monooxygenation"
            ],
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            "reactions": [
                {
                    "substrate": "N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O",
                    "products": [
                        "N=C(N)NCCC[C@@H]1NC(=O)[C@H](CC23OC2Nc2ccccc23)NC1=O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1038/s41589-022-01246-6"
                ]
            }
        },
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            "tailoring": [
                "Monooxygenation"
            ],
            "reactionSMARTS": "[#7:1]=[#6:2](-[#7:4]-[#6:5]-[#6:6]-[#6:7]\\[#6@:8]1-[#6:24](=[#8:25])-[#7:23]-[#6@@:12](\\[#6:13]-[#6:14](-[#6:16]2:[#6:21](-[#7:22]):[#6:20]:[#6:19]:[#6:18]:[#6:17]:2)=[#8:15])-[#6:10](=[#8:11])-[#7:9]-1)-[#7:3]>>[#7:1]=[#6:2](-[#7:4]-[#6:5]-[#6:6]-[#6:7]\\[#6@:8]1-[#6:24](=[#8:25])-[#7:23]-[#6@@:12](\\[#6:13]-[#6:14]2:[#6:16]3:[#6:21](:[#7:22]:[#8:15]:2):[#6:20]:[#6:19]:[#6:18]:[#6:17]:3)-[#6:10](=[#8:11])-[#7:9]-1)-[#7:3]",
            "reactions": [
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                    "substrate": "N=C(N)NCCC[C@@H]1NC(=O)[C@H](CC(=O)c2ccccc2N)NC1=O",
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                }
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            "evidence": {
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                    "doi:10.1038/s41589-022-01246-6"
                ]
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            "tailoring": [
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                "references": [
                    "doi:10.1038/s41589-022-01246-6"
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}