{
    "accession": "MITE0000143",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0002-6258-2080",
                "0000-0003-2992-1607",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 fixed reaction SMARTS numbering"
        },
        {
            "version": "2",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        }
    ],
    "enzyme": {
        "name": "AvaC",
        "description": "Kynurenine formamidase",
        "references": [
            "doi:10.1038/s41589-022-01246-6"
        ],
        "databaseIds": {
            "uniprot": "P9WEK4",
            "genpept": "UZP48215.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydrolysis"
            ],
            "reactionSMARTS": "[#6]-[#6](-[#7:4]-[#6:5]1:[#6:10](-[#6:11](-[#6:13]\\[#6@:14]2-[#6:27](=[#8:28])-[#7:26]-[#6@@:18](\\[#6:19]-[#6:20]-[#6:21]-[#7:22]-[#6:23](-[#7:25])=[#7:24])-[#6:16](=[#8:17])-[#7:15]-2)=[#8:12]):[#6:9]:[#6:8]:[#6:7]:[#6:6]:1)=[#8]>>[#7:24]=[#6:23](-[#7:22]-[#6:21]-[#6:20]-[#6:19]\\[#6@:18]1-[#6:16](=[#8:17])-[#7:15]-[#6@@:14](\\[#6:13]-[#6:11](-[#6:10]2:[#6:5](-[#7:4]):[#6:6]:[#6:7]:[#6:8]:[#6:9]:2)=[#8:12])-[#6:27](=[#8:28])-[#7:26]-1)-[#7:25]",
            "reactions": [
                {
                    "substrate": "CC(=O)Nc1ccccc1C(=O)C[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC1=O",
                    "products": [
                        "N=C(N)NCCC[C@@H]1NC(=O)[C@H](CC(=O)c2ccccc2N)NC1=O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1038/s41589-022-01246-6"
                ]
            },
            "databaseIds": {
                "rhea": "13009",
                "ec": "3.5.1.9"
            }
        }
    ]
}