{
    "accession": "MITE0000134",
    "comment": "Previously referenced retired MIBiG ID BGC0002857.",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 fixed reaction SMARTS numbering and database IDs. The original submission specified RefSeq ID XP_020879357.1, which was changed to its GenPept equivalent. Replaced CXSMARTS with normal SMARTS"
        },
        {
            "version": "2",
            "date": "2026-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBIG ID."
        }
    ],
    "enzyme": {
        "name": "THAS",
        "description": "Oxidosqualene cyclase",
        "references": [
            "doi:10.1038/s41467-020-19153-6"
        ],
        "databaseIds": {
            "uniprot": "UPI000A29AD50",
            "genpept": "CAH8278777.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Cyclization"
            ],
            "description": "Cyclases the intermediate in the thalianin pathway in Arabidopsis thaliana ssp. lyrata",
            "reactionSMARTS": "[#6@:1]1(-[#6:6]-[#6:7]-[#6:8](-[#6:10])=[#6:9]-[#6:11]-[#6:12]-[#6:13](-[#6:15])=[#6:14]-[#6:16]-[#6:17]-[#6:18]=[#6:19](-[#6:21])-[#6:20]-[#6:22]-[#6:23]=[#6:24](-[#6:26]-[#6:27]-[#6:28]=[#6:29](-[#6:31])-[#6:30])-[#6:25])-[#6:3](-[#6:5])(-[#6:4])-[#8:2]/1>>[#6@:1]1(-[#6:6]-[#6:7]-[#6@@:8]2(-[#6:14]3-[#6:16]-[#6:17]-[#6@@:18](/[#6])(-[#6:13]=3-[#6:12]-[#6:11]-[#6:9]-2-[#6@@:3]-1(\\[#6:5])/[#6:4])-[#6@:19](/[#6:21])-[#6:20]-[#6:22]-[#6:23]=[#6:24](-[#6:26]-[#6:27]-[#6:28]=[#6:29](-[#6:31])-[#6:30])-[#6:25])/[#6:10])/[#8:2]",
            "reactions": [
                {
                    "substrate": "CC(C)=CCC/C(C)=C/CCC(C)=CCC/C=C(\\C)CCC=C(C)CC[C@@H]1OC1(C)C",
                    "products": [
                        "CC(C)=CCCC(C)=CCC[C@@H](C)[C@@]1(C)CCC2=C1CCC1C(C)(C)[C@@H](O)CC[C@]21C"
                    ],
                    "isIntermediate": true,
                    "description": "Cyclizes 2,3-oxidosqualene to thalianol"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1038/s41467-020-19153-6"
                ]
            },
            "databaseIds": {
                "rhea": "31035",
                "ec": "4.2.1.124"
            }
        }
    ]
}