{
    "accession": "MITE0000130",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458",
                "0000-0001-7044-2419",
                "0000-0002-4187-2863",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-7493-459X"
            ],
            "comment": "Initial entry. Added reaction description"
        },
        {
            "version": "2",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        },
        {
            "version": "3",
            "date": "2025-10-27",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Replaced retired UniProtKB ID with UniParc ID"
        }
    ],
    "enzyme": {
        "name": "ThnH",
        "description": "Tryptophan 6-halogenase",
        "references": [
            "doi:10.1002/cbic.201500670"
        ],
        "databaseIds": {
            "uniprot": "UPI00078E7F2F",
            "genpept": "AMR44308.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Halogenation"
            ],
            "description": "chlorinates tryptophan to form 6-Cl-tryptophan (6-Cl-Trp)",
            "reactionSMARTS": "[#7:13]-[#6@@H:11](-[#6:10]-[c:7]1[c:8][n:9][c:5]2[c:4][c:3][c:2][c:1][c:6]12)-[#6:12](-[#8:15])=[O:16]>>[#7:13]-[#6@@H:11](-[#6:10]-[c:7]1[c:8][n:9][c:5]2[c:4][c:3]([Cl])[c:2][c:1][c:6]12)-[#6:12](-[#8:15])=[O:16]",
            "reactions": [
                {
                    "substrate": "N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O",
                    "products": [
                        "N[C@@H](Cc1c[nH]c2cc(Cl)ccc12)C(=O)O"
                    ],
                    "isIntermediate": true,
                    "description": "a chlorine atom is introduced in the indole ring of tryptophan."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "Inference from genomic data and chemical structure"
                ],
                "references": [
                    "doi:10.1002/cbic.201500670"
                ]
            },
            "databaseIds": {
                "rhea": "56528",
                "ec": "1.14.19.59"
            }
        }
    ]
}