{
    "accession": "MITE0000125",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458"
            ],
            "reviewers": [
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer fixed reactionSMARTS:reactionSMARTS."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-08-06",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Fixed enzyme name from JuiL to JuiI, added reaction description."
        }
    ],
    "enzyme": {
        "name": "JuiI",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1021/acs.orglett.0c02469"
        ],
        "databaseIds": {
            "uniprot": "A0A7G8Z073",
            "genpept": "QNL10608.1",
            "mibig": "BGC0002514"
        },
        "cofactors": {
            "organic": [
                "Heme"
            ],
            "inorganic": [
                "Fe"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Biaryl bond formation"
            ],
            "description": "Biaryl coupling of two julichrome Q6 units",
            "reactionSMARTS": "[#6:3]-[#6@H:2](-[#8:1])-[#6:4]-[#6:5](=[O:6])-[c:7]1[c:8](-[#6:19]-[#6@@H:20](-[#6:21])-[#8:22]-[#6:23](-[#6:24])=[O:25])[c:9][c:10]2[c:11][c:12][c:13][c:14](-[#8:15])[c:16]2[c:17]1-[#8:18].[#6:28]-[#6@H:27](-[#8:26])-[#6:29]-[#6:30](=[O:31])-[c:32]1[c:33](-[#6:44]-[#6@@H:45](-[#6:46])-[#8:47]-[#6:48](-[#6:49])=[O:50])[c:34][c:35]2[c:36][c:37][c:38][c:39](-[#8:40])[c:41]2[c:42]1-[#8:43]>>[#6:3]-[#6@H:2](-[#8:1])-[#6:4]-[#6:5](=[O:6])-[c:7]1[c:8](-[#6:44]-[#6@@H:45](-[#6:46])-[#8:47]-[#6:48](-[#6:49])=[O:50])[c:9][c:10]2[c:11][c:12][c:13]([c:14](-[#8:15])[c:16]2[c:17]1-[#8:18])-[c:19]1[c:20][c:21][c:22]2[c:23][c:24](-[#6:25]-[#6@@H:26](-[#6:27])-[#8:28]-[#6:29](-[#6:30])=[O:31])[c:32](-[#6:33](=[O:34])-[#6:35]-[#6@H:36](-[#6:37])-[#8:38])[c:39](-[#8:40])[c:41]2[c:42]1-[#8:43]",
            "reactions": [
                {
                    "substrate": "CC(=O)O[C@H](C)Cc1cc2cccc(O)c2c(O)c1C(=O)C[C@H](C)O.CC(=O)O[C@H](C)Cc1cc2cccc(O)c2c(O)c1C(=O)C[C@H](C)O",
                    "products": [
                        "CC(=O)O[C@H](C)Cc1cc2ccc(-c3ccc4cc(C[C@@H](C)OC(C)=O)c(C(=O)C[C@H](C)O)c(O)c4c3O)c(O)c2c(O)c1C(=O)C[C@H](C)O"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1021/acs.orglett.0c02469"
                ]
            }
        }
    ]
}