{
    "accession": "MITE0000123",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458"
            ],
            "reviewers": [
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer fixed reactionSMARTS:reactionSMARTS."
        },
        {
            "version": "2",
            "date": "2025-12-07",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added reaction description."
        }
    ],
    "enzyme": {
        "name": "JuiM",
        "description": "Acetyltransferase",
        "references": [
            "doi:10.1021/acs.orglett.0c02469"
        ],
        "databaseIds": {
            "uniprot": "A0A7G8Z071",
            "genpept": "QNL10606.1",
            "mibig": "BGC0002514"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Acetylation"
            ],
            "description": "Acetylates the nascent julichrome monomer",
            "reactionSMARTS": "[#6:3]-[#6@H:2](-[#8:1])-[#6:4]-[#6:5](=[O:6])-[c:7]1[c:8](-[#6:19]-[#6@@H:20](-[#6:21])-[#8:22])[c:9][c:10]2[c:11][c:12][c:13][c:14](-[#8:15])[c:16]2[c:17]1-[#8:18]>>[#6:3]-[#6@H:2](-[#8:1])-[#6:4]-[#6:5](=[O:6])-[c:7]1[c:8](-[#6:19]-[#6@@H:20](-[#6:21])-[#8:22]-[#6](-[#6])=[O])[c:9][c:10]2[c:11][c:12][c:13][c:14](-[#8:15])[c:16]2[c:17]1-[#8:18]",
            "reactions": [
                {
                    "substrate": "C[C@H](O)CC(=O)c1c(C[C@@H](C)O)cc2cccc(O)c2c1O",
                    "products": [
                        "CC(=O)O[C@H](C)Cc1cc2cccc(O)c2c(O)c1C(=O)C[C@H](C)O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1021/acs.orglett.0c02469"
                ]
            },
            "databaseIds": {
                "ec": "2.3"
            }
        }
    ]
}