{
    "accession": "MITE0000118",
    "status": "active",
    "comment": "Previously referenced retired MIBiG ID BGC0002076.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0002-4977-2541",
                "0000-0002-9747-3423",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6660-2715",
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 added reaction description. Reviewer 2 replaced reaction SMILES to reaction SMARTS"
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBiG BGC ID."
        }
    ],
    "enzyme": {
        "name": "AcaR",
        "description": "Oxidoreductase",
        "references": [
            "doi:10.1002/anie.201914154",
            "doi:10.1016/j.bmc.2006.05.039"
        ],
        "databaseIds": {
            "uniprot": "A0A5C4KWK7",
            "genpept": "TNB95040.1"
        },
        "cofactors": {
            "organic": [
                "NADP"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Reduction"
            ],
            "description": "reduction of exocxclic double bond in dehydroacaterin to acaterin",
            "reactionSMARTS": "[#6:1]=[#6:2]1-[#8:16]-[#6:14](=[#8:15])-[#6:4](-[#6@@:5](-[#6:7]-[#6:8]-[#6:9]-[#6:10]-[#6:11]-[#6:12]-[#6:13])/[#8:6])=[#6:3]-1>>[#6:13]-[#6:12]-[#6:11]-[#6:10]-[#6:9]-[#6:8]-[#6:7]-[#6@:5](-[#6:4]1-[#6:14](=[#8:15])-[#8:16]-[#6:2](-[#6:1])-[#6:3]=1)/[#8:6]",
            "reactions": [
                {
                    "substrate": "C=C1C=C([C@H](O)CCCCCCC)C(=O)O1",
                    "products": [
                        "CCCCCCC[C@@H](O)C1=CC(C)OC1=O"
                    ],
                    "isIntermediate": false,
                    "description": "reduction of 4,5-didehydroacaterin to acaterin"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1002/anie.201914154",
                    "doi:10.1016/j.bmc.2006.05.039"
                ]
            }
        }
    ]
}