{
    "accession": "MITE0000112",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0009-0001-3436-5302",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609",
                "0000-0003-0443-9902",
                "0000-0002-9747-3423"
            ],
            "comment": "Initial entry. Reviewer fixed reactionSMARTS:reactionSMARTS. Reviewer 2 reworked reaction SMARTS numbering. Reviewr 3 changed enzyme and reaction description"
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Replaced retired UniProtKB ID with UniParc ID. Removed spurious auxiliary Enzymes (referenced in MIBiG BGC)."
        }
    ],
    "enzyme": {
        "name": "Ngnp1",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1021/acschembio.9b01034"
        ],
        "databaseIds": {
            "uniprot": "UPI0010052BAD",
            "genpept": "AXG22409.1",
            "mibig": "BGC0002024"
        },
        "cofactors": {
            "inorganic": [
                "Fe"
            ],
            "organic": [
                "Heme"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydroxylation",
                "Oxidation"
            ],
            "description": "Hydroxylation at c-2",
            "reactionSMARTS": "[#6:1]-[#6:2]\\[#6@@:3]1-[#6@:25](\\[#6:26])-[#6:24]=[#6:22](-[#6:23])-[#6:21]2-[#6:9](-[#6:10]=[#6:11]-[#6:12]3-[#6:20]-2-[#6@@:18](/[#8:19])-[#6@@:16](/[#6:17])-[#6@@:14](/[#8:15])-[#6:13]-3)-[#6:8]-[#6:7]-[#6:5](=[#8:6])-[#8:4]-1>>[#6:1]-[#6:2]\\[#6@@:3]1-[#6@:25](\\[#6:26])-[#6:24]=[#6:22](-[#6:23])-[#6:21]2-[#6:9](-[#6:10]=[#6:11]-[#6:12]3-[#6:20]-2-[#6@@:18](/[#8:19])-[#6@@:16](/[#6:17])-[#6@@:14](/[#8:15])-[#6:13]-3)-[#6:8]-[#6@:7](\\[#8])-[#6:5](=[#8:6])-[#8:4]-1",
            "reactions": [
                {
                    "substrate": "CC[C@H]1OC(=O)CCC2C=CC3C[C@H](O)[C@H](C)[C@H](O)C3C2/C(C)=C/[C@H]1C",
                    "products": [
                        "CC[C@H]1OC(=O)[C@@H](O)CC2C=CC3C[C@H](O)[C@H](C)[C@H](O)C3C2C(C)=C[C@H]1C"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1021/acschembio.9b01034"
                ]
            }
        }
    ]
}