{
    "accession": "MITE0000109",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6660-2715"
            ],
            "comment": "Initial entry. Reviwer 1 added description of reaction"
        },
        {
            "version": "2",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Reworked reaction SMARTS to implement editorial decision (removed residual product)."
        },
        {
            "version": "3",
            "date": "2025-10-27",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Replaced retired UniProtKB ID with UniParc ID"
        }
    ],
    "enzyme": {
        "name": "CmxA",
        "description": "L-lysine cyclodeaminase",
        "references": [
            "doi:10.1002/anie.201808028"
        ],
        "databaseIds": {
            "uniprot": "UPI000E33162C",
            "genpept": "AXM43051.1",
            "mibig": "BGC0001945"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Cyclization",
                "Deamination"
            ],
            "description": "cyclization and deamination of lysine to pipecolic acid",
            "reactionSMARTS": "[#7:1]-[#6:2]-[#6:3]-[#6:4]-[#6:5]-[#6@@:6](-[#6:8](=[#8:10])-[#8:9])/[#7:7]>>[#6:3]1-[#6:2]-[#7:7]-[#6@:6](/[#6:8](=[#8:10])-[#8:9])-[#6:5]-[#6:4]-1",
            "reactions": [
                {
                    "substrate": "NCCCC[C@H](N)C(=O)O",
                    "products": [
                        "O=C(O)[C@@H]1CCCCN1"
                    ],
                    "isIntermediate": true,
                    "description": "cyclization and deamination of lysine to pipecolic acid"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Inference from genomic data and chemical structure"
                ],
                "references": [
                    "doi:10.1002/anie.201808028"
                ]
            },
            "databaseIds": {
                "rhea": "34304"
            }
        }
    ]
}