{
    "accession": "MITE0000108",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer fixed reactionSMARTS:reactionSMARTS."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        }
    ],
    "enzyme": {
        "name": "CldC",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1007/s10295-015-1694-6"
        ],
        "databaseIds": {
            "uniprot": "A0A0H5B5M5",
            "genpept": "BAR97452.1",
            "mibig": "BGC0001910"
        },
        "cofactors": {
            "inorganic": [
                "Fe"
            ],
            "organic": [
                "Heme"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "reactionSMARTS": "[#6:10]\\[#6:9](-[#6:11]=[#6:12])=[#6:8]/[#6:7]-[#6@H:6]1-[#6:4](=[#6:5])-[#6:3]-[#6:2]-[#6@H:1]2[C:18]([#6:19])([#6:20])[#6:17]-[#6:16]-[#6:15][C@:13]12[#6:14]>>[#6:12]\\[#6:11](-[#6:13]=[#6:14])=[#6:10]/[#6:9]-[#6@H:8]1[C@:5]2([#6:6]-[#8:7]2)[#6@@H:3](-[#8:4])-[#6:2]-[#6@H:1]2[C:20]([#6])([#6])[#6:19]-[#6:18]-[#6:17][C@:15]12[#6:16]",
            "reactions": [
                {
                    "substrate": "C=C/C(C)=C/C[C@H]1C(=C)CC[C@H]2C(C)(C)CCC[C@]12C",
                    "products": [
                        "C=C/C(C)=C/C[C@@H]1[C@@]2(C)CCCC(C)(C)[C@@H]2C[C@H](O)[C@@]12CO2"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1007/s10295-015-1694-6"
                ]
            }
        }
    ]
}