{
    "accession": "MITE0000106",
    "status": "active",
    "comment": "Previously referenced retired MIBiG entry BGC0001664.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer fixed reactionSMARTS:reactionSMARTS."
        },
        {
            "version": "2",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        },
        {
            "version": "3",
            "date": "2025-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBiG BGC."
        }
    ],
    "enzyme": {
        "name": "MstE",
        "description": "Terpene cyclase",
        "references": [
            "doi:10.1002/anie.201611617"
        ],
        "databaseIds": {
            "uniprot": "A0A2D1CM82",
            "genpept": "ATN39899.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Cyclization"
            ],
            "reactionSMARTS": "[#6:4]\\[#6:3](-[#6:5])=[#6:2]\\[#6:1]-[#6:6]-[#6:7](-[#6:8])=[#6:9]-[#6:10]-[#6:11]\\[#6:12](-[#6:13])=[#6:14]\\[#6:15]-[#6:16]-[#6:17](-[#6:18])=[#6:19]-[#6:20]-[c:21]1[c:31][c:27]([c:26][c:24](-[#8:25])[c:22]1-[#8:23])-[#6:28](-[#8:29])=[O:30]>>[H:13][C@:12]12[#6:14]-[c:15]3[c:25]([c:21]([c:20][c:18](-[#8:19])[c:16]3-[#8:17])-[#6:22](-[#8:23])=[O:24])[C@:26]1([#6:27])[#6:28]-[#6:29][C@:30]1([H:31])[C@:10]2([#6:11])[#6:9]-[#6:8][C@:6]2([H:7])[C:3]([#6:4])([#6:5])[#6:2]-[#6:1]-[#6][C@@]12[#6]",
            "reactions": [
                {
                    "substrate": "CC(C)=CCCC(C)=CCC/C(C)=C/CCC(C)=CCc1cc(C(=O)O)cc(O)c1O",
                    "products": [
                        "CC1(C)CCC[C@@]2(C)[C@@H]3CC[C@@]4(C)c5c(C(=O)O)cc(O)c(O)c5C[C@@H]4[C@@]3(C)CC[C@H]12"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1002/anie.201611617"
                ]
            }
        }
    ]
}