{
    "accession": "MITE0000103",
    "status": "active",
    "comment": "Previously referenced retired MIBiG entry BGC0001487.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0002-6077-7490",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609",
                "0000-0003-0443-9902",
                "0000-0002-9747-3423"
            ],
            "comment": "Initial entry. Reviewer fixed reactionSMARTS:reactionSMARTS. Reviewer 2 fixed typo. Reviewer 3 changed enzyme and reaction description"
        },
        {
            "version": "2",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        },
        {
            "version": "3",
            "date": "2025-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBiG BGC."
        }
    ],
    "enzyme": {
        "name": "TrlF",
        "description": "Decarboxylase/Hydrolase",
        "references": [
            "doi:10.1039/D4SC01715C"
        ],
        "databaseIds": {
            "uniprot": "A0A2S1JZI6",
            "genpept": "AWF83810.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Other"
            ],
            "description": "Cleaves off CoA from 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA",
            "reactionSMARTS": "[#6:1][C:2]([#6:3])([#6:4]-[#8:5][P:6]([#8:7])(=[O:8])[#8:9][P:10]([#8:11])(=[O:12])[#8:13]-[#6:14]-[#6@H:15]-1-[#8:16]-[#6@H:17](-[#6@H:18](-[#8:19])-[#6@@H:20]-1-[#8:21][P:22]([#8:23])([#8:24])=[O:25])-[n:26]1[c:27][n:28][c:29]2[c:30](-[#7:31])[n:32][c:33][n:34][c:35]12)[#6@@H:36](-[#8:37])-[#6:38](=[O:39])-[#7:40]-[#6:41]-[#6:42]-[#6:43](=[O:44])-[#7:45]-[#6:46]-[#6:47]-[#16:48]-[#16:49]-[#6:50](=[O:51])-[#6:52]-1=[#6:53](-[#8:54])-[#6:55]-[#6:56]=[#6:57]-[#6:58]=[#6:59]-1>>[#8:1]-[#6:2](=[O:3])-[#6:4]-1=[#6:5](-[#8:6])-[#6:7]-[#6:8]=[#6:9]-[#6:10]=[#6:11]-1",
            "reactions": [
                {
                    "substrate": "CC(C)(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)[C@@H](O)C(=O)NCCC(=O)NCCSSC(=O)C1=C(O)CC=CC=C1",
                    "products": [
                        "O=C(O)C1=C(O)CC=CC=C1"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1039/D4SC01715C"
                ]
            }
        }
    ]
}