{
    "accession": "MITE0000102",
    "status": "active",
    "comment": "Previously referenced retired MIBiG entry BGC0001487.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0002-6077-7490",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6660-2715"
            ],
            "comment": "Initial entry. Reviewer 1 changed enzyme type and added enzyme description."
        },
        {
            "version": "2",
            "date": "2025-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBiG BGC."
        }
    ],
    "enzyme": {
        "name": "TrlE",
        "description": "Flavoprotein monooxygenase",
        "references": [
            "doi:10.1039/D4SC01715C"
        ],
        "databaseIds": {
            "uniprot": "A0A2S1JZI9",
            "genpept": "AWF83809.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Other"
            ],
            "description": "Combines hydroxylation, decarboxylation and oxidation to generate tropolone from dihydrotropone-2-carboxylate",
            "reactionSMARTS": "[#8:1]-[#6:4](=[O:2])-[#6:11]-1=[#6:7](-[#8:3])-[#6:6]-[#6:5]=[#6:8]-[#6:9]=[#6:10]-1>>[#8:3]-[#6:7]-1=[#6:6]-[#6:5]=[#6:8]-[#6:9]=[#6:10]-[#6:11]-1=O",
            "reactions": [
                {
                    "substrate": "O=C(O)C1=C(O)CC=CC=C1",
                    "products": [
                        "O=c1cccccc1O"
                    ],
                    "isIntermediate": false,
                    "description": "Combines hydroxylation, decarboxylation and oxidation to generate tropolone from dihydrotropone-2-carboxylate"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1039/D4SC01715C"
                ]
            }
        }
    ]
}