{
    "accession": "MITE0000096",
    "status": "active",
    "comment": "Cofactorless. Previously referenced retired MIBiG entry BGC0001378.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609",
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer partially fixed reactionSMARTS:reactionSMARTS, validation still not passing. Reviewer 2 fixed reaction SMARTS, reaction passing."
        },
        {
            "version": "2",
            "date": "2025-10-27",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Replaced retired UniProtKB ID with UniParc ID"
        },
        {
            "version": "3",
            "date": "2025-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBiG BGC."
        }
    ],
    "enzyme": {
        "name": "TnmJ",
        "description": "Oxygenase",
        "references": [
            "doi:10.1038/s41589-023-01476-2"
        ],
        "databaseIds": {
            "uniprot": "UPI00076F29F8",
            "genpept": "AME18009.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Dioxygenation"
            ],
            "reactionSMARTS": "[#6:1]-[#8:2]-[#6:3]1-[#6:33]2-[#6:34]3(-[#6:11]4-[#6:12]-[#6:13](-[#6:15]5:[#6:25](-[#8:26]):[#6:24]6:[#6:19](:[#6:20]:[#6:21]:[#6:22]:[#6:23]:6):[#6:17](-[#8:18]):[#6:16]:5-[#6:10]-4=[#7:9]-[#6:8](-[#6:27]#[#6:28]-[#6:29]=[#6:30]-[#6:31]#[#6:32]-2)-[#6:7]-3=[#6:5](-[#6:6])-[#6:4]=1)=[#8:14])-[#6:35]=[#8:36]>>[#6:1]-[#8:2]-[#6:3]1-[#6:33]2-[#6:34]3-[#6:11]4:[#6:12]:[#6:13](:[#6:15]5-[#6:25](=[#8:26])-[#6:24]6:[#6:19](:[#6:20]:[#6:21]:[#6:22]:[#6:23]:6)-[#6:17](=[#8:18])-[#6:16]:5:[#6:10]:4-[#7:9]-[#6:8](-[#6:27]#[#6:28]-[#6:29]=[#6:30]-[#6:31]#[#6:32]-2)-[#6:7]-3=[#6:5](-[#6:6])-[#6:4]=1)-[#8:14]",
            "reactions": [
                {
                    "substrate": "COC1=CC(C)=C2C3C#CC=CC#CC1C2(C=O)C1CC(=O)c2c(c(O)c4ccccc4c2O)C1=N3",
                    "products": [
                        "COC1=CC(C)=C2C3C#CC=CC#CC1C2c1cc(O)c2c(c1N3)C(=O)c1ccccc1C2=O"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay",
                    "Site-directed mutagenesis",
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1038/s41589-023-01476-2"
                ]
            }
        }
    ]
}