{
    "accession": "MITE0000093",
    "status": "active",
    "comment": "Note: structural revision of phormidolide A -- 10.1039/d0cc03055d. Previously referenced retired MIBiG entry BGC0001350.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3588-892X",
                "0000-0002-8323-5416"
            ],
            "reviewers": [
                "0000-0001-6660-2715",
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 expanded enzyme description. Reviewer 2 replaced CXSMARTS with normal SMARTS"
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBiG BGC, replaced retired UniProtKB ID with UniParc"
        }
    ],
    "enzyme": {
        "name": "PhmJ",
        "description": "FAD-dependent halogenase",
        "references": [
            "doi:10.1002/cbic.201500467"
        ],
        "databaseIds": {
            "uniprot": "UPI00076F78A1",
            "genpept": "AMH40426.1"
        },
        "cofactors": {
            "organic": [
                "FAD"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Halogenation"
            ],
            "description": "PhmJ forms the vinyl bromination in phormidolide A",
            "reactionSMARTS": "[#6:1]=[#6:2](-[#6:5](-[#6:7]\\[#6@@:8](-[#8:54]-[#6:55](-[#6:57]-[#6:58]-[#6:59]-[#6:60]-[#6:61]-[#6:62]-[#6:63]-[#6:64]-[#6:65]-[#6:66]-[#6:67]-[#6:68]-[#6:69]-[#6:70]-[#6:71])=[#8:56])-[#6:9]-[#6@:10](-[#6@@:12](-[#6@:14](-[#6:16]-[#6@:17](-[#6:19](-[#6@:22](-[#6:24]-[#6:25](=[#6:27]-[#6@:28](-[#6@@:30]1(-[#6@:52]2-[#6:53]-[#6@:33](-[#6:34]-[#6:35](=[#6:37]-[#6:38](-[#6:40]-[#6@@:41](-[#6:43]-[#6:44]=[#6:45]-[#6:46](=[#6:48]-[#6:49](-[#8:51]\\2)=[#8:50])-[#6:47])/[#8:42])=[#6:39])-[#6:36])\\[#8:32]-1)/[#6:31])\\[#8:29])-[#6:26])\\[#8:23])(-[#6:21])-[#6:20])\\[#8:18])\\[#8:15])\\[#6:13])\\[#8:11])=[#6:6])-[#8:3]-[#6:4]>>[#6:39]=[#6:38]1-[#6:40]-[#6@:41](/[#8:42])-[#6:43]-[#6:44]=[#6:45]-[#6:46](-[#6:47])=[#6:48]-[#6:49](=[#8:50])-[#8:51]-[#6@:52]2-[#6@:30](-[#8:32]-[#6@:33](-[#6:53]\\2)\\[#6:34]-[#6:35](-[#6:36])=[#6:37]-1)(-[#6@@:28](-[#6:27]=[#6:25](-[#6:24]-[#6@@:22](-[#6:19](-[#6@@:17](-[#6:16]-[#6@@:14](-[#6@:12](-[#6@@:10](-[#6:9]\\[#6@:8](-[#8:54]-[#6:55](-[#6:57]-[#6:58]-[#6:59]-[#6:60]-[#6:61]-[#6:62]-[#6:63]-[#6:64]-[#6:65]-[#6:66]-[#6:67]-[#6:68]-[#6:69]-[#6:70]-[#6:71])=[#8:56])-[#6:7]-[#6:5](-[#6:2](-[#8:3]-[#6:4])=[#6:1]-[Br])=[#6:6])\\[#8:11])\\[#6:13])\\[#8:15])\\[#8:18])(-[#6:21])-[#6:20])\\[#8:23])-[#6:26])\\[#8:29])/[#6:31]",
            "reactions": [
                {
                    "substrate": "C=C1/C=C(\\C)C[C@H]2C[C@@H](OC(=O)/C=C(C)/C=C/C[C@@H](O)C1)[C@@](C)([C@H](O)/C=C(\\C)C[C@H](O)C(C)(C)[C@H](O)C[C@H](O)[C@@H](C)[C@H](O)C[C@@H](CC(=C)C(=C)OC)OC(=O)CCCCCCCCCCCCCCC)O2",
                    "products": [
                        "C=C1C=C(C)C[C@H]2C[C@@H](OC(=O)C=C(C)C=CC[C@@H](O)C1)[C@@](C)([C@H](O)C=C(C)C[C@H](O)C(C)(C)[C@H](O)C[C@H](O)[C@@H](C)[C@H](O)C[C@@H](CC(=C)C(=CBr)OC)OC(=O)CCCCCCCCCCCCCCC)O2"
                    ],
                    "isIntermediate": false,
                    "description": "Bromination of vinyl group"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Inference from genomic data and chemical structure"
                ],
                "references": [
                    "doi:10.1002/cbic.201500467"
                ]
            }
        }
    ]
}