{
    "accession": "MITE0000092",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0009-0006-9871-5187"
            ],
            "reviewers": [
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Fixed proper halogenation enumeration."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-10-27",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Replaced retired UniProtKB ID with UniParc ID"
        }
    ],
    "enzyme": {
        "name": "BorH",
        "description": "Flavin-dependent halogenase",
        "references": [
            "doi:10.1002/cbic.201900667"
        ],
        "databaseIds": {
            "uniprot": "UPI0002C6BC4B",
            "genpept": "AGI62217.1",
            "mibig": "BGC0001335"
        },
        "cofactors": {
            "organic": [
                "FAD"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Halogenation"
            ],
            "description": "Tryptophan-6 halogenation",
            "reactionSMARTS": "[#7:1]-[#6:2](-[#6:3]-[c:4]1[c:5][nH1:6][c:7]2[c:8][c:9][c:10][c:11][c:12]12)-[#6:13](-[#8:14])=[O:15]>>[#7:1]-[#6:2](-[#6:3]-[c:4]1[c:5][nH1:6][c:7]2[c:8][c:9](-[#17,#35:10])[c:11][c:12][c:13]12)-[#6:14](-[#8:15])=[O]",
            "reactions": [
                {
                    "substrate": "NC(Cc1c[nH]c2ccccc12)C(=O)O",
                    "products": [
                        "NC(Cc1c[nH]c2cc(Br)ccc12)C(=O)O",
                        "NC(Cc1c[nH]c2cc(Cl)ccc12)C(=O)O"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1002/cbic.201900667"
                ]
            }
        }
    ]
}