{
    "accession": "MITE0000088",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458"
            ],
            "reviewers": [
                "0000-0001-6534-6609",
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer partially fixed reactionSMARTS:reactionSMARTS, validation still not passing. Reviewer 2 redrew product, reaction passes."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        }
    ],
    "enzyme": {
        "name": "TlmF",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1002/cbic.201700090"
        ],
        "databaseIds": {
            "uniprot": "A0A0P0G6I4",
            "genpept": "ALJ49912.1",
            "mibig": "BGC0001237"
        },
        "cofactors": {
            "inorganic": [
                "Fe"
            ],
            "organic": [
                "Heme"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "reactionSMARTS": "[#6:1]\\[#6:2]=[#6:3](/[#6:4])\\[#6:5]=[#6:6](/[#6:7])\\[#6:8](\\[#8:9])=[#6:10](\\[#6:11])-[#6:12](-[#16-:13])=[O:14]>>[#6:1]\\[#6:2]=[#6:3](/[#6:4])-[#6:5]1-[#8:6][C:7]1([#6:8])[#6:9](\\[#8:10])=[#6:11](\\[#6:12])-[#6:13](-[#16-:14])=[O]",
            "reactions": [
                {
                    "substrate": "C/C=C(C)/C=C(C)/C(O)=C(/C)C(=O)[S-]",
                    "products": [
                        "C/C=C(\\C)C1OC1(C)C(O)=C(C)C(=O)[S-]"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1002/cbic.201700090"
                ]
            }
        }
    ]
}