{
    "accession": "MITE0000086",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer reworked reaction SMARTS to make it RDKit-compatible, reaction passes."
        },
        {
            "version": "2",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        }
    ],
    "enzyme": {
        "name": "NapH1",
        "description": "Vanadium-dependent chloroperoxidase ",
        "references": [
            "doi:10.1021/ja201088k"
        ],
        "databaseIds": {
            "uniprot": "A7KGZ9",
            "genpept": "ABS50458.1",
            "mibig": "BGC0001079"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Heterocyclization",
                "Halogenation"
            ],
            "reactionSMARTS": "[#6:1]-[#6:2](=[#6:4]-[#6:5]-[#6:6]-[#6:7](=[#6:9]-[#6:10]-[#6@:11]1(-[#6@@:26](-[#6:28]-[#6:29]=[#6:30](-[#6:32])-[#6:31])(\\[Cl:27])-[#6:24](=[#8:25])-[#6:23]2:[#6:15](:[#6:16]:[#6:17](:[#6:19](:[#6:21]:2-[#8:22])-[#6:20])-[#8:18])-[#6:13]-1=[#8:14])/[#8:12])-[#6:8])-[#6:3]>>[#6:1]-[#6:2](=[#6:4]-[#6:5]-[#6:6]-[#6:7](=[#6:9]-[#6:10]\\[#6@:11]12-[#6:13](=[#8:14])-[#6:15]3:[#6:16]:[#6:17](:[#6:19](:[#6:21](-[#8:22]):[#6:23]:3-[#6:24](=[#8:25])-[#6@@:26]-1(\\[Cl:27])-[#6:28]-[#6@@:29](/[Cl])-[#6:30](-[#6:32])(-[#6:31])-[#8:12]-2)-[#6:20])-[#8:18])-[#6:8])-[#6:3]",
            "reactions": [
                {
                    "substrate": "CC(C)=CCC/C(C)=C/C[C@]1(O)C(=O)c2cc(O)c(C)c(O)c2C(=O)[C@@]1(Cl)CC=C(C)C",
                    "products": [
                        "CC(C)=CCCC(C)=CC[C@@]12OC(C)(C)[C@H](Cl)C[C@]1(Cl)C(=O)c1c(cc(O)c(C)c1O)C2=O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1021/ja201088k"
                ]
            }
        }
    ]
}