{
    "accession": "MITE0000085",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458"
            ],
            "reviewers": [
                "0000-0001-6534-6609",
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer 1 partially fixed reactionSMARTS:reactionSMARTS, validation still not passing. Reviewer 2 fixed aromaticity of SMILES and reaction SMARTS, reaction passing"
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        }
    ],
    "enzyme": {
        "name": "NapB5",
        "description": "C-methyltransferase",
        "references": [
            "doi:10.1074/jbc.M611046200"
        ],
        "databaseIds": {
            "uniprot": "A7KH06",
            "genpept": "ABS50465.1",
            "mibig": "BGC0001079"
        },
        "cofactors": {
            "inorganic": [
                "FeS"
            ],
            "organic": [
                "SAM"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Methylation"
            ],
            "reactionSMARTS": "[#8:1]-[#6:2]1:[#6:8]:[#6:7]2-[#6:9](-[#6:11](=[#6:13]-[#6:14](=[#8:15])-[#6:6]:2:[#6:4](-[#8:5]):[#6:3]:1)-[#8:12])=[#8:10]>>[#8:1]-[#6:2]1:[#6:8]:[#6:7]2-[#6:9](-[#6:11](=[#6:13]-[#6:14](=[#8:15])-[#6:6]:2:[#6:4](-[#8:5]):[#6:3]:1-[#6])-[#8:12])=[#8:10]",
            "reactions": [
                {
                    "substrate": "O=C1C(O)=CC(=O)c2c(O)cc(O)cc21",
                    "products": [
                        "Cc1c(O)cc2c(c1O)C(=O)C=C(O)C2=O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Inference from genomic data and chemical structure"
                ],
                "references": [
                    "doi:10.1074/jbc.M611046200",
                    "doi:10.1021/ja201088k"
                ]
            }
        }
    ]
}