{
    "accession": "MITE0000082",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-4129-2890"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 reworked reaction SMARTS to remove RDKit-incompatible frequency variation CXSMARTS layer."
        },
        {
            "version": "2",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        }
    ],
    "enzyme": {
        "name": "AgqC",
        "description": "O-methyltransferase",
        "references": [
            "doi:10.1002/cbic.201000628"
        ],
        "databaseIds": {
            "uniprot": "I0HIZ1",
            "genpept": "BAL92978.1",
            "mibig": "BGC0001077"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Methylation"
            ],
            "reactionSMARTS": "[#6:1]-[#6:2](-[#6:4]-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]-[#6:11]-[#6:12]-[#6:13]-[#6:14]-[#6:15]-[#6:16]-[#6:17]1:[#6:24](-[#8:25]):[#6:22](-[#8:23]):[#6:21]:[#6:19](-[#8:20]):[#6:18]:1)-[#6:3]>>[#6]-[#8:23]-[#6:22]1:[#6:24](-[#8:25]):[#6:17](-[#6:16]-[#6:15]-[#6:14]-[#6:13]-[#6:12]-[#6:11]-[#6:10]-[#6:9]-[#6:8]-[#6:7]-[#6:6]-[#6:5]-[#6:4]-[#6:2](-[#6:1])-[#6:3]):[#6:18]:[#6:19](-[#8:20]):[#6:21]:1",
            "reactions": [
                {
                    "substrate": "CC(C)CCCCCCCCCCCCCc1cc(O)cc(O)c1O",
                    "products": [
                        "COc1cc(O)cc(CCCCCCCCCCCCCC(C)C)c1O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1002/cbic.201000628"
                ]
            }
        },
        {
            "tailoring": [
                "Methylation"
            ],
            "reactionSMARTS": "[#6:1]-[#6:2](-[#6:4]-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]-[#6:11]-[#6:12]-[#6:13]-[#6:14]-[#6:15]-[#6:16]1:[#6:23](-[#8:24]):[#6:21](-[#8:22]):[#6:20]:[#6:18](-[#8:19]):[#6:17]:1)-[#6:3]>>[#6]-[#8:22]-[#6:21]1:[#6:23](-[#8:24]):[#6:16](-[#6:15]-[#6:14]-[#6:13]-[#6:12]-[#6:11]-[#6:10]-[#6:9]-[#6:8]-[#6:7]-[#6:6]-[#6:5]-[#6:4]-[#6:2](-[#6:1])-[#6:3]):[#6:17]:[#6:18](-[#8:19]):[#6:20]:1",
            "reactions": [
                {
                    "substrate": "CC(C)CCCCCCCCCCCCc1cc(O)cc(O)c1O",
                    "products": [
                        "COc1cc(O)cc(CCCCCCCCCCCCC(C)C)c1O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1002/cbic.201000628"
                ]
            }
        },
        {
            "tailoring": [
                "Methylation"
            ],
            "reactionSMARTS": "[#6:1]-[#6:2]-[#6:3](-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]-[#6:11]-[#6:12]-[#6:13]-[#6:14]-[#6:15]-[#6:16]-[#6:17]1:[#6:24](-[#8:25]):[#6:22](-[#8:23]):[#6:21]:[#6:19](-[#8:20]):[#6:18]:1)-[#6:4]>>[#6:1]-[#6:2]-[#6:3](-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]-[#6:11]-[#6:12]-[#6:13]-[#6:14]-[#6:15]-[#6:16]-[#6:17]1:[#6:24](-[#8:25]):[#6:22](-[#8:23]-[#6]):[#6:21]:[#6:19](-[#8:20]):[#6:18]:1)-[#6:4]",
            "reactions": [
                {
                    "substrate": "CCC(C)CCCCCCCCCCCCc1cc(O)cc(O)c1O",
                    "products": [
                        "CCC(C)CCCCCCCCCCCCc1cc(O)cc(OC)c1O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1002/cbic.201000628"
                ]
            }
        },
        {
            "tailoring": [
                "Methylation"
            ],
            "reactionSMARTS": "[#6:1]-[#6:2]-[#6:3]-[#6:4]-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]-[#6:11]-[#6:12]-[#6:13]-[#6:14]-[#6:15]-[#6:16]1:[#6:23](-[#8:24]):[#6:21](-[#8:22]):[#6:20]:[#6:18](-[#8:19]):[#6:17]:1>>[#6:1]-[#6:2]-[#6:3]-[#6:4]-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]-[#6:11]-[#6:12]-[#6:13]-[#6:14]-[#6:15]-[#6:16]1:[#6:23](-[#8:24]):[#6:21](-[#8:22]-[#6]):[#6:20]:[#6:18](-[#8:19]):[#6:17]:1",
            "reactions": [
                {
                    "substrate": "CCCCCCCCCCCCCCCc1cc(O)cc(O)c1O",
                    "products": [
                        "CCCCCCCCCCCCCCCc1cc(O)cc(OC)c1O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1002/cbic.201000628"
                ]
            }
        }
    ]
}