{
    "accession": "MITE0000080",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 added auxiliary enzyme."
        }
    ],
    "enzyme": {
        "name": "PokMT1",
        "description": "C-methyltransferase",
        "references": [
            "doi:10.1002/cbic.200800823"
        ],
        "databaseIds": {
            "uniprot": "C0JWB3",
            "genpept": "ACN64833.1",
            "mibig": "BGC0001061"
        },
        "auxiliaryEnzymes": [
            {
                "name": "PokM3",
                "description": "CoA ligase",
                "databaseIds": {
                    "uniprot": "C0JWB0",
                    "genpept": "ACN64830.1"
                }
            }
        ]
    },
    "reactions": [
        {
            "tailoring": [
                "Methylation"
            ],
            "description": "C-methylation of methylsalicylic acid bound to coenzyme A. Auxiliary enzyme PokM3 needed to load methylsalicylic acid on coenzyme A.",
            "reactionSMARTS": "[#6:8]-[c:2]1[c:3][c:4][c:5][c:6](-[#8:9])[c:1]1-[#6:7](=[O:10])-[#16:11]-[#6:57]-[#6:56]-[#7:55]-[#6:53](=[O:54])-[#6:52]-[#6:51]-[#7:50]-[#6:48](=[O:49])-[#6@H:47](-[#8:58])[C:13]([#6:12])([#6:14])[#6:15]-[#8:16][P:17]([#8:19])(=[O:18])[#8:20][P:21]([#8:23])(=[O:22])[#8:24]-[#6:25]-[#6@H:26]-1-[#8:30]-[#6@H:29](-[#6@H:28](-[#8:41])-[#6@@H:27]-1-[#8:42][P:43]([#8:45])([#8:46])=[O:44])-[n:31]1[c:32][n:33][c:34]2[c:35](-[#7:40])[n:36][c:37][n:38][c:39]12>>[#6]-[c:5]1[c:4][c:3][c:2](-[#6:8])[c:1](-[#6:7](=[O:10])-[#16:11]-[#6:57]-[#6:56]-[#7:55]-[#6:53](=[O:54])-[#6:52]-[#6:51]-[#7:50]-[#6:48](=[O:49])-[#6@H:47](-[#8:58])[C:13]([#6:12])([#6:14])[#6:15]-[#8:16][P:17]([#8:19])(=[O:18])[#8:20][P:21]([#8:23])(=[O:22])[#8:24]-[#6:25]-[#6@H:26]-2-[#8:30]-[#6@H:29](-[#6@H:28](-[#8:41])-[#6@@H:27]-2-[#8:42][P:43]([#8:45])([#8:46])=[O:44])-[n:31]2[c:32][n:33][c:34]3[c:35](-[#7:40])[n:36][c:37][n:38][c:39]23)[c:6]1-[#8:9]",
            "reactions": [
                {
                    "substrate": "Cc1cccc(O)c1C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O",
                    "products": [
                        "Cc1ccc(C)c(C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2OP(=O)(O)O)c1O"
                    ],
                    "isIntermediate": true,
                    "description": "Converts CoA-bound 6-methylsalicylic acid to 3,6-dimethylsalicylic acid"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay",
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1021/acs.biochem.7b01219"
                ]
            }
        }
    ]
}