{
    "accession": "MITE0000077",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 added auxiliary enzyme."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        }
    ],
    "enzyme": {
        "name": "MdpB1",
        "description": "C-methyltransferase",
        "references": [
            "doi:10.1021/ja1050814"
        ],
        "databaseIds": {
            "uniprot": "B0BLM5",
            "genpept": "ABY66020.1",
            "mibig": "BGC0001008"
        },
        "auxiliaryEnzymes": [
            {
                "name": "MdpB2",
                "description": "CoA ligase",
                "databaseIds": {
                    "uniprot": "B0BLM7",
                    "genpept": "ABY66018.1"
                }
            }
        ],
        "cofactors": {
            "inorganic": [
                "FeS"
            ],
            "organic": [
                "SAM"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Methylation"
            ],
            "description": "C-methylation of methylsalicylic acid bound to coenzyme A. Auxiliary enzyme MdpB2 needed to load methylsalicylic acid on coenzyme A.",
            "reactionSMARTS": "[#6:1]-[#6:2]1:[#6:8](-[#6:9](-[#16:11]-[#6:12]-[#6:13]-[#7:14]-[#6:15](-[#6:17]-[#6:18]-[#7:19]-[#6:20](-[#6@@:22](-[#6:24](-[#6:27]-[#8:28]-[#15:29](-[#8:32]-[#15:33](-[#8:36]-[#6:37]/[#6@@:38]2-[#6@@:53](\\[#8:54]-[#15:55](-[#8:58])(-[#8:57])=[#8:56])-[#6@@:51](\\[#8:52])-[#6@:40](/[#7:41]3:[#6:50]4:[#6:44](:[#6:45](:[#7:47]:[#6:48]:[#7:49]:4)-[#7:46]):[#7:43]:[#6:42]:3)-[#8:39]-2)(-[#8:35])=[#8:34])(-[#8:31])=[#8:30])(-[#6:26])-[#6:25])/[#8:23])=[#8:21])=[#8:16])=[#8:10]):[#6:6](-[#8:7]):[#6:5]:[#6:4]:[#6:3]:1>>[#6]-[#6:5]1:[#6:6](-[#8:7]):[#6:8](-[#6:9](-[#16:11]-[#6:12]-[#6:13]-[#7:14]-[#6:15](-[#6:17]-[#6:18]-[#7:19]-[#6:20](-[#6@@:22](-[#6:24](-[#6:27]-[#8:28]-[#15:29](-[#8:32]-[#15:33](-[#8:36]-[#6:37]/[#6@@:38]2-[#6@@:53](\\[#8:54]-[#15:55](-[#8:58])(-[#8:57])=[#8:56])-[#6@@:51](\\[#8:52])-[#6@:40](/[#7:41]3:[#6:50]4:[#6:44](:[#6:45](:[#7:47]:[#6:48]:[#7:49]:4)-[#7:46]):[#7:43]:[#6:42]:3)-[#8:39]-2)(-[#8:35])=[#8:34])(-[#8:31])=[#8:30])(-[#6:26])-[#6:25])/[#8:23])=[#8:21])=[#8:16])=[#8:10]):[#6:2](-[#6:1]):[#6:3]:[#6:4]:1",
            "reactions": [
                {
                    "substrate": "Cc1cccc(O)c1C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O",
                    "products": [
                        "Cc1ccc(C)c(C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2OP(=O)(O)O)c1O"
                    ],
                    "isIntermediate": true,
                    "description": "Converts CoA-bound 6-methylsalicylic acid to 3,6-dimethylsalicylic acid"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1021/ja1050814"
                ]
            }
        }
    ]
}