{
    "accession": "MITE0000076",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0009-0006-9871-5187",
                "0000-0002-8323-5416"
            ],
            "reviewers": [
                "0000-0001-6406-4394"
            ],
            "comment": "Initial entry. Reviewer 1 simplified reaction SMARTS as JamD is quite promiscuous. Added descriptions for reactions, and added ionidation example from SI of paper"
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "Added cofactor information"
        }
    ],
    "enzyme": {
        "name": "JamD",
        "description": "Flavin-dependent halogenase",
        "references": [
            "doi:10.1021/jacs.3c05750"
        ],
        "databaseIds": {
            "uniprot": "Q6E7K6",
            "genpept": "AAS98776.1",
            "mibig": "BGC0001001"
        },
        "cofactors": {
            "organic": [
                "FAD"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Halogenation"
            ],
            "description": "Flavin-dependent bromination of terminal alkyne",
            "reactionSMARTS": "[C:1][C:2]#[CH1:3]>>[C:1][C:2]#[CH0:3][Br]",
            "reactions": [
                {
                    "substrate": "C#CCCCC(=CCl)CCC(C)C=CCCC(=O)NCCC(=CC(=O)N1C(=O)C=CC1C)OC",
                    "products": [
                        "COC(=CC(=O)N1C(=O)C=CC1C)CCNC(=O)CCC=CC(C)CCC(=CCl)CCCC#CBr"
                    ],
                    "isIntermediate": true,
                    "description": "Bromination of jamaicamide B to jamaicamide A."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1021/jacs.3c05750"
                ]
            }
        },
        {
            "tailoring": [
                "Halogenation"
            ],
            "description": "Flavin-dependent iodination of terminal alkyne",
            "reactionSMARTS": "[C:1][C:2]#[CH1:3]>>[C:1][C:2]#[CH0:3][I]",
            "reactions": [
                {
                    "substrate": "C#CCCCC(=CCl)CCC(C)C=CCCC(=O)NCCC(=CC(=O)N1C(=O)C=CC1C)OC",
                    "products": [
                        "COC(=CC(=O)N1C(=O)C=CC1C)CCNC(=O)CCC=CC(C)CCC(=CCl)CCCC#CI"
                    ],
                    "isIntermediate": true,
                    "description": "Iodination of jamaicamide B to jamaicamide F."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1021/jacs.3c05750"
                ]
            }
        }
    ]
}