{
    "accession": "MITE0000075",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458",
                "0000-0001-7044-2419"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 fixed reaction, replaced wildcards in SMILES with full structures."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Fixed reaction SMARTS indexing."
        },
        {
            "version": "4",
            "date": "2026-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Replaced retired UniProtKB ID with UniParc ID."
        }
    ],
    "enzyme": {
        "name": "ClmM2",
        "description": "O-methyltransferase",
        "references": [
            "doi:10.1016/j.chembiol.2012.01.014"
        ],
        "databaseIds": {
            "uniprot": "UPI000249FC4F",
            "genpept": "CCC55909.1",
            "mibig": "BGC0000973"
        },
        "cofactors": {
            "inorganic": [
                "FeS"
            ],
            "organic": [
                "SAM"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Methylation"
            ],
            "description": "O-methylation of collismycin D",
            "reactionSMARTS": "[#6:1]-[#16:2]-[#6:3]1:[#6:15](-[#6:16]=[#7:17]-[#8:18]):[#7:14]:[#6:7](-[#6:8]2:[#7:13]:[#6:12]:[#6:11]:[#6:10]:[#6:9]:2):[#6:6]:[#6:4]:1-[#8:5]>>[#6:1]-[#16:2]-[#6:3]1:[#6:15](-[#6:16]=[#7:17]-[#8:18]):[#7:14]:[#6:7](-[#6:8]2:[#7:13]:[#6:12]:[#6:11]:[#6:10]:[#6:9]:2):[#6:6]:[#6:4]:1-[#8:5]-[#6]",
            "reactions": [
                {
                    "substrate": "CSc1c(O)cc(-c2ccccn2)nc1/C=N/O",
                    "products": [
                        "COc1cc(-c2ccccn2)nc(C=NO)c1SC"
                    ],
                    "isIntermediate": false,
                    "description": "O-methylation of collismycin D, resulting in collismycin A"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Inference from genomic data and chemical structure"
                ],
                "references": [
                    "doi:10.1016/j.chembiol.2012.01.014"
                ]
            }
        }
    ]
}