{
    "accession": "MITE0000074",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458",
                "0000-0001-7044-2419"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 reworked reaction SMARTS."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2026-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Replaced retired UniProtKB ID with UniParc ID."
        }
    ],
    "enzyme": {
        "name": "ClmM1",
        "description": "S-methyltransferase",
        "references": [
            "doi:10.1016/j.chembiol.2012.01.014"
        ],
        "databaseIds": {
            "uniprot": "UPI000249FC52",
            "genpept": "CCC55912.1",
            "mibig": "BGC0000973"
        },
        "cofactors": {
            "inorganic": [
                "FeS"
            ],
            "organic": [
                "SAM"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Methylation"
            ],
            "reactionSMARTS": "[#6:1]-[#6:2](-[#6:4]-[#6:5](-[#7:9]1:[#6:24](=[#8:25]):[#6:23]2:[#6:11](:[#6:12](:[#6:14]:[#6:15](:[#7:22]:2)-[#6:16]2:[#7:21]:[#6:20]:[#6:19]:[#6:18]:[#6:17]:2)-[#8:13]):[#16:10]:1)-[#6:6](-[#8:8])=[#8:7])-[#6:3]>>[#6]-[#16:10]-[#6:11]1:[#6:23](-[#6:24](-[#7:9]-[#6:5](-[#6:6](-[#8:8])=[#8:7])-[#6:4]-[#6:2](-[#6:3])-[#6:1])=[#8:25]):[#7:22]:[#6:15](-[#6:16]2:[#7:21]:[#6:20]:[#6:19]:[#6:18]:[#6:17]:2):[#6:14]:[#6:12]:1-[#8:13]",
            "reactions": [
                {
                    "substrate": "CC(C)CC(C(=O)O)n1sc2c(O)cc(-c3ccccn3)nc2c1=O",
                    "products": [
                        "CSc1c(O)cc(-c2ccccn2)nc1C(=O)NC(CC(C)C)C(=O)O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1016/j.chembiol.2012.01.014"
                ]
            }
        }
    ]
}