{
    "accession": "MITE0000073",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458",
                "0000-0001-7044-2419"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "Initial entry. Reviewer 1 checked factual correctness, changed enzyme reaction description."
        },
        {
            "version": "2",
            "date": "2026-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Replaced retired UniProtKB ID with UniParc ID."
        }
    ],
    "enzyme": {
        "name": "ClmAH",
        "description": "Amidohydrolase",
        "references": [
            "doi:10.1016/j.chembiol.2012.01.014"
        ],
        "databaseIds": {
            "uniprot": "UPI000249FC56",
            "genpept": "CCC55916.1",
            "mibig": "BGC0000973"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydrolysis"
            ],
            "description": "removal of the leucine residue",
            "reactionSMARTS": "[#6:27]-[#16:16]-[c:11]1[c:10](-[#8:25])[c:9][c:8]([n:7][c:12]1-[#6:13](=[O:14])-[#7:15]-[#6:17](-[#6:18]-[#6:19](-[#6:20])-[#6:21])-[#6:22](-[#8:23])=[O:24])-[c:5]1[c:6][c:1][c:2][c:3][n:4]1>>[#6:27]-[#16:16]-[c:11]1[c:10](-[#8:25])[c:9][c:8]([n:7][c:12]1-[#6:13](-[#8])=[O:14])-[c:5]1[c:6][c:1][c:2][c:3][n:4]1",
            "reactions": [
                {
                    "substrate": "CSc1c(O)cc(-c2ccccn2)nc1C(=O)NC(CC(C)C)C(=O)O",
                    "products": [
                        "CSc1c(O)cc(-c2ccccn2)nc1C(=O)O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1016/j.chembiol.2012.01.014"
                ]
            }
        }
    ]
}