{
    "accession": "MITE0000071",
    "status": "active",
    "comment": "Flavin-dependent halogenase with phenolic substrate",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0009-0006-9871-5187"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 added abstract version of reaction"
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2026-02-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed MIBiG cross-reference due to genpept ID mismatch."
        },
        {
            "version": "4",
            "date": "2026-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Replaced retired UniProtKB ID with UniParc ID."
        }
    ],
    "enzyme": {
        "name": "Bmp2",
        "description": "Flavin-dependent halogenase",
        "references": [
            "doi:10.1038/nchembio.1564"
        ],
        "databaseIds": {
            "uniprot": "UPI0003C95F91",
            "genpept": "AHA34035.1"
        },
        "cofactors": {
            "organic": [
                "FAD"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Halogenation"
            ],
            "reactionSMARTS": "[#6:1]1:[#6:5]:[#6:4]:[#6:3]:[#7:2]:1>>[Br]-[#6:1]1:[#6:5](-[Br]):[#6:4](-[Br]):[#6:3](-[Br]):[nH:2]:1",
            "reactions": [
                {
                    "substrate": "c1cc[nH]c1",
                    "products": [
                        "Brc1[nH]c(Br)c(Br)c1Br"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1073/pnas.1519695113"
                ]
            }
        },
        {
            "tailoring": [
                "Halogenation"
            ],
            "reactionSMARTS": "[#6]-[#6](-[#6])(-[#6]-[#8]-[#15](=[#8])(-[#8-])-[#8]-[#15](=[#8])(-[#8-])-[#8]-[#6]-[#6]1-[#6](-[#6](-[#6](-[#8]-1)-[#7]1:[#6]:[#7]:[#6]2:[#6](:[#7]:[#6]:[#7]:[#6]:1:2)-[#7])-[#8])-[#8]-[#15](=[#8])(-[#8-])-[#8-])-[#6](-[#6](=[#8])-[#7]-[#6]-[#6]-[#6](=[#8])-[#7]-[#6]-[#6]-[#16]-[#6](=[#8])-[#6]1:[#6]:[#6]:[#6]:[#7H]:1)-[#8]>>[#6]1(:[#6](:[#7H]:[#6](:[#6]:1-[#35])-[#35])-[#35])-[#35]",
            "reactions": [
                {
                    "substrate": "CC(C)(COP(=O)([O-])OP(=O)([O-])OCC1OC(n2cnc3c(N)ncnc32)C(O)C1OP(=O)([O-])[O-])C(O)C(=O)NCCC(=O)NCCSC(=O)c1ccc[nH]1",
                    "products": [
                        "Brc1[nH]c(Br)c(Br)c1Br"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1073/pnas.1519695113"
                ]
            }
        }
    ]
}