{
    "accession": "MITE0000070",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-1763-2525"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "Initial entry. Reviewer 1 checked crosslinks, factual correctness, added reference and reaction description"
        },
        {
            "version": "2",
            "date": "2026-02-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Fixed genpept ID to correspond with MIBiG."
        }
    ],
    "enzyme": {
        "name": "RebC",
        "description": "Putative FAD-monooxygenase",
        "references": [
            "doi:10.1021/ja063898m",
            "doi:10.1021/ja0743801"
        ],
        "databaseIds": {
            "uniprot": "Q8KI25",
            "genpept": "BAC10676.1",
            "mibig": "BGC0000821"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "description": "FAD-dependent enzyme RebC catalyse the oxidation of two carboxylic acids to form a maleimide ring. RebC cofactor is FAD.",
            "reactionSMARTS": "[#8:1]-[#6:2](=[O:3])-[c:4]1[n:28][c:27](-[#6:29](-[#8:30])=[O:31])[c:26]2[c:5]1[c:6]1[c:15]3[c:14][c:13][c:12][c:10]([Cl:11])[c:9]3[n:8][c:7]1[c:16]1[n:20][c:19]3[c:21]([Cl:22])[c:23][c:24][c:25][c:18]3[c:17]21>>[Cl:1][c:2]1[c:3][c:4][c:5][c:6]2[c:7]1[n:8][c:9]1[c:19]3[n:20][c:21]4[c:22]([Cl:23])[c:24][c:25][c:26][c:27]4[c:18]3[c:12]3-[#6:13](=[O:14])-[#7:15]-[#6:16](=[O:17])-[c:11]3[c:10]21",
            "reactions": [
                {
                    "substrate": "O=C(O)c1[nH]c(C(=O)O)c2c1c1c3cccc(Cl)c3[nH]c1c1[nH]c3c(Cl)cccc3c12",
                    "products": [
                        "O=C1NC(=O)c2c1c1c3cccc(Cl)c3[nH]c1c1[nH]c3c(Cl)cccc3c21"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/ja063898m",
                    "doi:10.1021/ja0743801"
                ]
            }
        }
    ]
}