{
    "accession": "MITE0000069",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-1763-2525"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer reworked reaction SMARTS to fix missing numbering"
        },
        {
            "version": "2",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        },
        {
            "version": "3",
            "date": "2026-01-24",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added reaction description. Reviewer improved description."
        },
        {
            "version": "4",
            "date": "2026-02-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Fixed genpept ID to correspond with MIBiG."
        }
    ],
    "enzyme": {
        "name": "RebH",
        "description": "Tryptophan halogenase",
        "references": [
            "doi:10.1016/s1074-5521(02)00126-6"
        ],
        "databaseIds": {
            "uniprot": "Q8KHZ8",
            "genpept": "BAC10682.1",
            "mibig": "BGC0000821"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Halogenation"
            ],
            "description": "Chlorinates the rebeccamycin intermediate.",
            "reactionSMARTS": "[#7:1]-[#6:2](-[#6:13](-[#8:15])=[#8:14])-[#6:3]-[#6:4]1:[#6:12]2:[#6:7](:[#6:8]:[#6:9]:[#6:10]:[#6:11]:2):[nH:6]:[#6:5]:1>>[#7:1]-[#6:2](-[#6:13](-[#8:15])=[#8:14])-[#6:3]-[#6:4]1:[#6:12]2:[#6:7](:[#6:8](:[#6:9]:[#6:10]:[#6:11]:2)-[Cl]):[nH:6]:[#6:5]:1",
            "reactions": [
                {
                    "substrate": "NC(Cc1c[nH]c2ccccc12)C(=O)O",
                    "products": [
                        "NC(Cc1c[nH]c2c(Cl)cccc12)C(=O)O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1073/pnas.0500755102"
                ]
            },
            "databaseIds": {
                "rhea": "26494",
                "ec": "1.14.19.9"
            }
        }
    ]
}