{
    "accession": "MITE0000068",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-1763-2525"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer fixed reaction SMARTS format."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2026-02-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Fixed genpept ID to correspond with MIBiG."
        }
    ],
    "enzyme": {
        "name": "RebO",
        "description": "Flavin-dependent L-tryptophan oxidase",
        "references": [
            "doi:10.1016/S1074-5521(02)00126-6"
        ],
        "databaseIds": {
            "uniprot": "Q8KHS0",
            "genpept": "BAC10674.1",
            "mibig": "BGC0000821"
        },
        "cofactors": {
            "inorganic": [
                "Fe"
            ],
            "organic": [
                "Flavin mononucleotide"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "reactionSMARTS": "[NH2:1][CH:2]([CH2:3][c:4]1[cH:5][nH:6][c:7]2[c:8]([Cl:16])[cH:9][cH:10][cH:11][c:12]12)[C:13]([OH:14])=[O:15]>>[O:1]=[C:2]([CH2:3][c:4]1[cH:5][nH:6][c:7]2[c:8]([Cl:16])[cH:9][cH:10][cH:11][c:12]12)[C:13]([OH:14])=[O:15]",
            "reactions": [
                {
                    "substrate": "NC(Cc1c[nH]c2c(Cl)cccc12)C(=O)O",
                    "products": [
                        "O=C(O)C(=O)Cc1c[nH]c2c(Cl)cccc12"
                    ],
                    "isIntermediate": true,
                    "description": "Should actually be L-chlorotryptophan."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1128/JB.187.6.2084-2092.2005"
                ]
            },
            "databaseIds": {
                "rhea": "27302",
                "ec": "1.4.3.23"
            }
        }
    ]
}