{
    "accession": "MITE0000067",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-1763-2525"
            ],
            "reviewers": [
                "0000-0001-6534-6609",
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer partially fixed reactionSMARTS:reactionSMARTS, validation still not passing. Reviewer partially fixed reactions:substrate, validation still not passing. Reviewer partially fixed reactions:products, validation still not passing. Review 2 redrew reaction SMARTS to take into account aromatic nitrogens in heterocycles."
        },
        {
            "version": "2",
            "date": "2026-02-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Fixed genpept ID to correspond with MIBiG."
        }
    ],
    "enzyme": {
        "name": "RebD",
        "description": "Dichlorochromopyrrolate synthase",
        "references": [
            "doi:10.1016/S1074-5521(02)00126-6",
            "doi:10.1021/ja056749x"
        ],
        "databaseIds": {
            "uniprot": "Q8KHV6",
            "genpept": "BAC10675.1",
            "mibig": "BGC0000821"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "reactionSMARTS": "[#8:1]-[#6:2](-[#6:4](-[#6:6]-[#6:7]1:[#6:16]2:[#6:10](:[#6:11](:[#6:13]:[#6:14]:[#6:15]:2)-[Cl:12]):[nH:9]:[#6:8]:1)=[#8:5])=[#8:3]>>[#8:1]-[#6:2](-[#6:4]1:[#6:6](-[#6:7]2:[#6:16]3:[#6:10](:[#6:11](:[#6:13]:[#6:14]:[#6:15]:3)-[Cl:12]):[nH:9]:[#6:8]:2):[#6](-[#6]2:[#6]3:[#6](:[#6](:[#6]:[#6]:[#6]:3)-[Cl]):[nH]:[#6]:2):[#6](-[#6](=[#8])-[#8]):[nH]:1)=[#8:3]",
            "reactions": [
                {
                    "substrate": "O=C(O)C(=O)Cc1c[nH]c2c(Cl)cccc12",
                    "products": [
                        "O=C(O)c1[nH]c(C(=O)O)c(-c2c[nH]c3c(Cl)cccc23)c1-c1c[nH]c2c(Cl)cccc12"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/ja056749x"
                ]
            },
            "databaseIds": {
                "rhea": "27393",
                "ec": "1.21.98.2"
            }
        }
    ]
}