{
    "accession": "MITE0000066",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-1763-2525"
            ],
            "reviewers": [
                "0000-0001-6534-6609",
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer partially fixed reactionSMARTS:reactionSMARTS, validation still not passing. Reviewer 2 reworked reaction SMARTS, reaction passing."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        },
        {
            "version": "4",
            "date": "2026-01-07",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added reaction description, cofactor."
        },
        {
            "version": "5",
            "date": "2026-02-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Fixed genpept ID to correspond with MIBiG."
        }
    ],
    "enzyme": {
        "name": "RebP",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1021/ja9003365"
        ],
        "databaseIds": {
            "uniprot": "Q8KIC8",
            "genpept": "BAC10677.1",
            "mibig": "BGC0000821"
        },
        "cofactors": {
            "organic": [
                "Heme"
            ],
            "inorganic": [
                "Fe"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "description": "Oxidative cyclization of chromopyrrolic acid.",
            "reactionSMARTS": "[#8:1]=[#6:2](-[#6:4]1:[#6:21](-[#6:22]2:[#6:31]3:[#6:25](:[#6:26](:[#6:28]:[#6:29]:[#6:30]:3)-[Cl:27]):[#7:24]:[#6:23]:2):[#6:10](-[#6:11]2:[#6:20]3:[#6:14](:[#6:15](:[#6:17]:[#6:18]:[#6:19]:3)-[Cl:16]):[#7:13]:[#6:12]:2):[#6:6](-[#6:7](-[#8:9])=[#8:8]):[#7:5]:1)-[#8:3]>>[#8:8]=[#6:7](-[#6:6]1:[#6:10]2:[#6:11]3:[#6:12](:[#6:23]4:[#6:22](:[#6:21]:2:[#6:4](-[#6:2](-[#8:3])=[#8:1]):[#7:5]:1):[#6:31]1:[#6:25](:[#6:26](:[#6:28]:[#6:29]:[#6:30]:1)-[Cl:27]):[#7:24]:4):[#7:13]:[#6:14]1:[#6:20]:3:[#6:19]:[#6:18]:[#6:17]:[#6:15]:1-[Cl:16])-[#8:9]",
            "reactions": [
                {
                    "substrate": "O=C(O)c1[nH]c(C(=O)O)c(-c2c[nH]c3c(Cl)cccc23)c1-c1c[nH]c2c(Cl)cccc12",
                    "products": [
                        "O=C(O)c1[nH]c(C(=O)O)c2c1c1c3cccc(Cl)c3[nH]c1c1[nH]c3c(Cl)cccc3c12"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/ja9003365"
                ]
            }
        }
    ]
}