{
    "accession": "MITE0000065",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviwer 1 reworked reaction SMARTS and added descriptions."
        }
    ],
    "enzyme": {
        "name": "PtlE",
        "description": "Baeyer-Villiger monooxygenase",
        "references": [
            "doi:10.1021/bi060419n"
        ],
        "databaseIds": {
            "uniprot": "Q82IY8",
            "genpept": "BAC70705.1",
            "mibig": "BGC0000678"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "description": "Catalyzes the flavin-dependent Baeyer-Villiger oxidation in the biosynthesis of neopentalenolactone",
            "reactionSMARTS": "[#6:1]/[#6@:2]1-[#6@@:18]23-[#6@:6](-[#6:7](=[#6:11]-[#6:12]-2-[#6:13]-[#6:14](-[#6:17]/3)(-[#6:16])-[#6:15])-[#6:8](-[#8:10])=[#8:9])\\[#6:5]-[#6:3]-1=[#8:4]>>[#6:1]/[#6@:2]1-[#6@@:18]23-[#6@:6](-[#6:7](=[#6:11]-[#6:12]-2-[#6:13]-[#6:14](-[#6:17]/3)(-[#6:15])-[#6:16])-[#6:8](-[#8:10])=[#8:9])\\[#6:5]-[#8]-[#6:3]-1=[#8:4]",
            "reactions": [
                {
                    "substrate": "C[C@@H]1C(=O)C[C@H]2C(C(=O)O)=CC3CC(C)(C)C[C@]312",
                    "products": [
                        "C[C@@H]1C(=O)OC[C@H]2C(C(=O)O)=CC3CC(C)(C)C[C@]312"
                    ],
                    "isIntermediate": true,
                    "description": "Converts 1-deoxy-11-oxopentalenic acid to neopentalenolactone D"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1021/bi1019786"
                ]
            },
            "databaseIds": {
                "rhea": "34639",
                "ec": "1.14.13.171"
            }
        }
    ]
}