{
    "accession": "MITE0000063",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 fixed reaction SMARTS of reaction 2 by explicitly stating the valence of the dehydrated carbon and replaced CXSMARTS with regular SMARTS."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        }
    ],
    "enzyme": {
        "name": "PtlD",
        "description": "Non-heme iron-dependent dehydrogenase/oxygenase ",
        "references": [
            "doi:10.1021/bi1019786"
        ],
        "databaseIds": {
            "uniprot": "Q82IY7",
            "genpept": "BAC70706.1",
            "mibig": "BGC0000678"
        },
        "cofactors": {
            "inorganic": [
                "Fe"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "reactionSMARTS": "[#6:1]=[#6:2]1-[#6@@:19]23-[#6@:7](-[#6:8](=[#6:12]-[#6:13]-2-[#6:14]-[#6:15](-[#6:18]\\3)(-[#6:17])-[#6:16])-[#6:9](-[#8:11])=[#8:10])/[#6:6]-[#8:5]-[#6:3]-1=[#8:4]>>[#6:16]-[#6:15]1(-[#6:18]\\[#6@@:19]23-[#6@@:7](/[#6:6]-[#8:5]-[#6:3](-[#6:2]4-2-[#8]-[#6:1]-4)=[#8:4])-[#6:8](-[#6:9](-[#8:11])=[#8:10])=[#6:12]-[#6:13]-3-[#6:14]-1)-[#6:17]",
            "reactions": [
                {
                    "substrate": "C=C1C(=O)OC[C@H]2C(C(=O)O)=CC3CC(C)(C)C[C@@]132",
                    "products": [
                        "CC1(C[C@@]23[C@@H](COC(C42OC4)=O)C(C(O)=O)=CC3C1)C"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay",
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1021/bi1019786"
                ]
            },
            "databaseIds": {
                "rhea": "34579",
                "ec": "1.14.11.36"
            }
        },
        {
            "tailoring": [
                "Dehydration"
            ],
            "reactionSMARTS": "[#6:1]\\[#6@:2]1-[#6@@:19]23-[#6@:7](-[#6:8](=[#6:12]-[#6:13]-2-[#6:14]-[#6:15](-[#6:18]\\3)(-[#6:17])-[#6:16])-[#6:9](-[#8:11])=[#8:10])/[#6:6]-[#8:5]-[#6:3]-1=[#8:4]>>[#6:1]=[#6&H0:2]1-[#6@@:19]23-[#6@:7](-[#6:8](=[#6:12]-[#6:13]-2-[#6:14]-[#6:15](-[#6:18]\\3)(-[#6:17])-[#6:16])-[#6:9](-[#8:11])=[#8:10])/[#6:6]-[#8:5]-[#6:3]-1=[#8:4]",
            "reactions": [
                {
                    "substrate": "C[C@@H]1C(=O)OC[C@H]2C(C(=O)O)=CC3CC(C)(C)C[C@]312",
                    "products": [
                        "C=C1C(=O)OC[C@H]2C(C(=O)O)=CC3CC(C)(C)C[C@@]132"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay",
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1021/bi1019786"
                ]
            }
        }
    ]
}