{
    "accession": "MITE0000024",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0009-0006-9871-5187",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 changed reaction SMARTS and substrate/product example to show actual intermediate reaction as described in the publication."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0003-4819-2251"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2026-01-24",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added reaction description. Reviewer fixed typo."
        }
    ],
    "enzyme": {
        "name": "XanH",
        "description": "FAD Halogenase",
        "references": [
            "doi:10.1128/AEM.01225-20"
        ],
        "databaseIds": {
            "uniprot": "I1SKW0",
            "genpept": "ADE22292.1",
            "mibig": "BGC0000279"
        },
        "cofactors": {
            "organic": [
                "FAD"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Halogenation"
            ],
            "description": "Chlorinates the xantholipin intermediate.",
            "reactionSMARTS": "[#8:1]-[#6:2]1:[#6:17]2:[#6:6](:[#6:7](:[#6:9]3:[#6:15](:[#8:16]:2):[#6:14](-[#8:18]-[#6:19]):[#6:13]2-[#6:20]-[#6:21]-[#6:22]4:[#6:34](-[#6:12]:2:[#6:10]:3-[#8:11]):[#6:32](-[#8:33]):[#6:31](:[#6:24](-[#6:25]-[#6:26](=[#8:35])-[#6:27]):[#6:23]:4)-[#6:29](=[#8:30])-[#8:28])=[#8:8]):[#6:5]:[#6:4]:[#6:3]:1>>[#8:1]-[#6:2]1:[#6:17]2:[#6:6](:[#6:7](:[#6:9]3:[#6:15](:[#8:16]:2):[#6:14](-[#8:18]-[#6:19]):[#6:13]2-[#6:20]-[#6:21]-[#6:22]4:[#6:34](-[#6:12]:2:[#6:10]:3-[#8:11]):[#6:32](-[#8:33]):[#6:31](:[#6:24](-[#6:25]-[#6:26](=[#8:35])-[#6:27]):[#6:23]:4)-[#6:29](=[#8:30])-[#8:28])=[#8:8]):[#6:5]:[#6:4]:[#6:3]:1-[Cl]",
            "reactions": [
                {
                    "substrate": "COc1c2c(c(O)c3c(=O)c4cccc(O)c4oc13)-c1c(cc(CC(C)=O)c(C(=O)O)c1O)CC2",
                    "products": [
                        "COc1c2c(c(O)c3c(=O)c4ccc(Cl)c(O)c4oc13)-c1c(cc(CC(C)=O)c(C(=O)O)c1O)CC2"
                    ],
                    "isIntermediate": true,
                    "description": "Intermediate product in the xantholipin biosynthetic pathway. "
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1128/AEM.01225-20"
                ]
            }
        }
    ]
}