{
    "accession": "MITE0000017",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0003-3002-6458",
                "0000-0002-9747-3423"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 fixed reaction SMARTS, reaction passes."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0003-4819-2251"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        }
    ],
    "enzyme": {
        "name": "MtmW",
        "description": "Ketoreductase",
        "references": [
            "doi:10.1002/anie.201910241"
        ],
        "databaseIds": {
            "uniprot": "Q194Q1",
            "genpept": "CAK50787.1",
            "mibig": "BGC0000247"
        },
        "cofactors": {
            "organic": [
                "NADP"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Reduction"
            ],
            "reactionSMARTS": "[#6:1]-[#8:2]/[#6@@:3](-[#6@:11]1-[#6@:47](\\[#8:48]-[#6:49]2-[#8:76]-[#6:74](-[#6:75])-[#6:72](-[#8:73])-[#6:51](-[#8:52]-[#6:53]3-[#8:71]-[#6:69](-[#6:70])-[#6:67](-[#8:68])-[#6:55](-[#8:56]-[#6:57]4-[#8:66]-[#6:64](-[#6:65])-[#6:62](-[#8:63])-[#6:59](-[#8:61])(-[#6])-[#6:58]-4)-[#6:54]-3)-[#6:50]-2)-[#6:45](=[#8])-[#6:44]2:[#6:13](:[#6:14]:[#6:15]3:[#6:41](:[#6:42]:2-[#8]):[#6:39](-[#8]):[#6:37](-[#6]):[#6:17](-[#8:18]-[#6:19]2-[#8:36]-[#6:34](-[#6:35])-[#6:32](-[#8:33])-[#6:21](-[#8:22]-[#6:23]4-[#8:31]-[#6:29](-[#6:30])-[#6:27](-[#8:28])-[#6:25](-[#8:26])-[#6:24]-4)-[#6:20]-2):[#6:16]:3)-[#6:12]/1)-[#6:4](-[#6@@:6](-[#6:8](=[#8:10])-[#6:9])/[#8:7])=[#8]>>[#6:1]-[#8:2]/[#6@@:9](-[#6@:37]1-[#6@:17](\\[#8:18]-[#6:19]2-[#8:36]-[#6:34](-[#6:35])-[#6:32](-[#8:33])-[#6:21](-[#8:22]-[#6:49]3-[#8:76]-[#6:74](-[#6:75])-[#6:72](-[#8:73])-[#6:51](-[#8:52]-[#6:53]4-[#8:71]-[#6:69](-[#6:70])-[#6:67](-[#8:68])-[#6:55](-[#8:56])(-[#6])-[#6:54]-4)-[#6:50]-3)-[#6:20]-2)-[#6:16](=[#8])-[#6:15]2:[#6:41](:[#6:42]:[#6:44]3:[#6:13](:[#6:14]:2-[#8]):[#6:12](-[#8]):[#6:11](-[#6:3]):[#6:47](-[#8:48]-[#6:23]2-[#8:31]-[#6:29](-[#6:30])-[#6:27](-[#8:28])-[#6:25](-[#8:26]-[#6:57]4-[#8:66]-[#6:64](-[#6:65])-[#6:62](-[#8:63])-[#6:59](-[#8:61])-[#6:58]-4)-[#6:24]-2):[#6:45]:3)-[#6:39]/1)-[#6:8](-[#6@@:6](-[#6@:4](-[#8])/[#6])/[#8:7])=[#8:10]",
            "reactions": [
                {
                    "substrate": "CO[C@H](C(=O)[C@H](O)C(C)=O)[C@@H]1Cc2cc3cc(OC4CC(OC5CC(O)C(O)C(C)O5)C(O)C(C)O4)c(C)c(O)c3c(O)c2C(=O)[C@H]1OC1CC(OC2CC(OC3CC(C)(O)C(O)C(C)O3)C(O)C(C)O2)C(O)C(C)O1",
                    "products": [
                        "CO[C@H](C(=O)[C@H](O)[C@@H](C)O)[C@@H]1Cc2cc3cc(OC4CC(OC5CC(O)C(O)C(C)O5)C(O)C(C)O4)c(C)c(O)c3c(O)c2C(=O)[C@H]1OC1CC(OC2CC(OC3CC(C)(O)C(O)C(C)O3)C(O)C(C)O2)C(O)C(C)O1"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1002/anie.201910241"
                ]
            }
        }
    ]
}