{
    "accession": "MITE0000013",
    "status": "active",
    "comment": "Was connected to retired MIBiG BGC0000230.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0001-7411-5925",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer 1 had to remove part of the reaction SMARTS to allow matching of the intended substrate in RDKit."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2026-07-02",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBiG BGC reference (was BGC0000230)."
        }
    ],
    "enzyme": {
        "name": "GrhO6",
        "description": "Flavoprotein monooxygenase",
        "references": [
            "doi:10.1038/s41467-021-21432-9",
            "doi:10.1039/d2sc01952c"
        ],
        "databaseIds": {
            "uniprot": "Q8KSX5",
            "genpept": "AAM33673.1"
        },
        "cofactors": {
            "organic": [
                "FAD"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Monooxygenation"
            ],
            "reactionSMARTS": "[#6:33]1(-[#6:9]2:[#6:8](-[#8:35]):[#6:7]3:[#6:6](:[#6:4](-[#8:5]):[#6:3](:[#6:38]:[#6:36]:3-[#8:37])-[#8:2]-[#6:1]):[#6:11](:[#6:10]:2-[#6:98](=[#8:99])-[#8:15]-[#6:16]2-1-[#8:17]-[#6:18]1:[#6:23](-[#8:24]):[#6:22]:[#6:21]:[#6:20]:[#6:19]:1-[#6:31]-[#6:32]-2)-[#8:12])=[#8:34]>>[#6:9]12:[#6:8](-[#8:35]):[#6:7]3:[#6:6](:[#6:11](:[#6:10]:1-[#8:15]-[#6:16]1(-[#8:17]-[#6:18]4:[#6:23](-[#8:24]):[#6:22]:[#6:21]:[#6:20]:[#6:19]:4-[#6:31]-[#6:32]-1)-[#6:33]-2=[#8:34])-[#8:12]):[#6:4](-[#8:5]):[#6:3](:[#6:38]:[#6:36]:3-[#8:37])-[#8:2]-[#6:1]",
            "reactions": [
                {
                    "substrate": "COc1cc(O)c2c(O)c3c(c(O)c2c1O)C(=O)OC1(CCc2cc4cc(C)oc(=O)c4c(O)c2O1)C3=O",
                    "products": [
                        "COc1cc(O)c2c(O)c3c(c(O)c2c1O)OC1(CCc2cc4cc(C)oc(=O)c4c(O)c2O1)C3=O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1038/s41467-021-21432-9",
                    "doi:10.1039/d2sc01952c"
                ]
            }
        }
    ]
}