{
    "accession": "MITE0000012",
    "status": "active",
    "comment": "Was connected to retired MIBiG BGC0000230.",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0001-7411-5925",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer reviewed reaction SMARTS and removed partial stereochemistry of the substrate-product reaction pair."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2026-07-02",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBiG BGC reference (was BGC0000230)."
        }
    ],
    "enzyme": {
        "name": "GrhO5",
        "description": "Flavoprotein monooxygenase",
        "references": [
            "doi:10.1038/s41467-021-21432-9",
            "doi:10.1002/anie.202109384"
        ],
        "databaseIds": {
            "uniprot": "Q8KSX7",
            "genpept": "AAM33672.1"
        },
        "cofactors": {
            "organic": [
                "FAD"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Monooxygenation"
            ],
            "reactionSMARTS": "[#6:1]1(=[#8])-[#6:32](-[#8:33]-[#6:34])=[#6:31]-[#6:29](=[#8])-[#6:28]2:[#6:2]-1:[#6:3](-[#8:38]):[#6:4]1:[#6:25](:[#6:26]:2-[#8:27])-[#6:23](=[#8:24])-[#6:21]2(-[#8:22])-[#6:7](-[#8:37])(-[#6:8]3:[#6:18](-[#6:19]-[#6:20]-2):[#6:17]:[#6:16]2:[#6:11](:[#6:12](=[#8:36]):[#8:13]:[#6:14](-[#6:35]):[#6:15]:2):[#6:9]:3-[#8:10])-[#6:5]-1=[#8:6]>>[#6:1]1(-[#8]):[#6:32](-[#8:33]-[#6:34]):[#6:31]:[#6:29](-[#8]):[#6:28]2:[#6:2]:1:[#6:3](-[#8:38]):[#6:4]1:[#6:25](:[#6:26]:2-[#8:27])-[#6:23](=[#8:24])-[#6:21]2(-[#6:20]-[#6:19]-[#6:18]3:[#6:8](:[#6:9](-[#8:10]):[#6:11]4:[#6:16](:[#6:17]:3):[#6:15]:[#6:14](-[#6:35]):[#8:13]:[#6:12]:4=[#8:36])-[#8:22]-2)-[#8]-[#6:7]-1(-[#6:5](=[#8:6])-[#8])-[#8:37]",
            "reactions": [
                {
                    "substrate": "COC1=CC(=O)c2c(O)c3c(c(O)c2C1=O)C(=O)C1(O)c2c(cc4cc(C)oc(=O)c4c2O)CCC1(O)C3=O",
                    "products": [
                        "COc1cc(O)c2c(O)c3c(c(O)c2c1O)C(O)(C(=O)O)OC1(CCc2cc4cc(C)oc(=O)c4c(O)c2O1)C3=O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1002/anie.202109384",
                    "doi:10.1038/s41467-021-21432-9"
                ]
            }
        }
    ]
}